Respiratory distress syndrome of newborn. Respiratory distress syndrome of newborn
Conditions
Interventions
Intervention 1: Intervention group: neonates receive budesonide 0.25 mg/kg in addition to intratracheal surfactant. Intervention 2: Control group: neonates receive intratracheal surfactant 2.5 cc/kg (
Sponsors
Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
1 Days to 3 Days
Inclusion criteria
Inclusion criteria: gestation age 26-30 weeks birth weight less than 1250 grams respiratory distress syndrome
Exclusion criteria
Exclusion criteria: 5 minute Apgar score less than 4 congenital heart disease except patent ductus arteriosus and atrial septal defect necrotizing entrocololitis major congenital anomalies, esophageal atresia, diaphragmatic hernia chromosomal anomalies shock
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reintubation in first 3 days after extubation. Timepoint: We evaluate the neonate immediately after intervention and daily till 3 days after intervention and extubation. Method of measurement: tracheal reintubation.;Need to second doses of surfactant. Timepoint: Daily till day 3 of birth and 3 days after intervention. Method of measurement: surfactant administration.;Bronchopulmonary dysplasia. Timepoint: Daily till 28 days after birth and day 28 after intervention. Method of measurement: need to supplemental oxygen. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactManizheh Mostafa Gharehbaghi
Tabriz University of Medical Sciences
Outcome results
None listed