Severe mood disorders resistant to treatment (Major depressive disorder or Bipolar disorder) requiring Electroconvulsive Therapy (ECT). ?????? ??????? ?????? ?????? ???? ???? ????????? ?????????
Conditions
Interventions
Intervention 1: Intervention group: Intervention group 1: Patients receive a combination of intravenous dexmedetomidine (1 mcg/kg) and thiopental sodium (4 mg/kg) along with succinylcholine (0.5 mg/kg
Sponsors
Rasht University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Age between 18 and 70 years ASA physical status class I or II Candidate for electroconvulsive therapy (ECT) as determined by a psychiatrist No contraindications to dexmedetomidine, propofol, or thiopental sodium Written informed consent obtained
Exclusion criteria
Exclusion criteria: Severe systemic diseases (ASA class III or higher) Known allergy to study medications Pregnancy or breastfeeding Unstable cardiovascular, respiratory, renal, or hepatic conditions High fever or active acute infection
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in heart rate (HR) in patients undergoing ECT in response to different anesthetic drug combinations. Timepoint: Before anesthesia, immediately after anesthesia, at seizure onset, immediately after seizure, 30 minutes after ECT, 24 hours after ECT. Method of measurement: Heart rate will be measured using ECG monitoring at each defined time point. | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of induced seizure following electroconvulsive therapy in patients receiving different anesthetic combinations. Timepoint: During ECT (from seizure onset to end of clonic activity). Method of measurement: Measured by direct clinical observation of motor activity using cuff method and time recording with stopwatch. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactCyrus Emir Alavi
Rasht University of Medical Sciences
Outcome results
None listed