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Effectiveness of Pregabalin and Nortriptyline on neuropathic pain in post-burn injuries

Effectiveness of Pregabalin and Nortriptyline on neuropathic pain in post-burn injuries

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
IRCT
Registry ID
IRCT20100501003844N4
Enrollment
60
Registered
2022-02-09
Start date
2021-07-06
Completion date
Unknown
Last updated
2022-03-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neuropathic pain. G89.29

Interventions

Intervention 1: Pregabalin The initial dose of the drug at the beginning of the study was 75 mg tablets of Sobhan Iran Company twice a day, Sobhan Company of Iran. Intervention 2: Nortriptyline receiv

Sponsors

Rasht University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Having an age of 65-18 years History of 5% or more burns above body level Have a pain score of 4 or higher (moderate to severe pain) based on the Brief Pain Inventory (BPI-P) Informed written consent and the ability to confirm in writing the participation in the study No history of allergy to pregabalin and nortriptyline Ability to swallow capsules Not pregnant and communicating with the research team.

Exclusion criteria

Exclusion criteria: History of consecutive use of any anticonvulsant medication during and after the burn History of pre-burn neuropathic pain A specific history of mental illness or substance abuse before and after burns

Design outcomes

Primary

MeasureTime frame
Pain score less than 4. Timepoint: In the recovery unit (0 hours) and 24 hours after the procedure, pain intensity is measured in two groups with pain criterion (BPI-P). Method of measurement: In this way, people are asked to show their pain intensity on a 10 cm ruler. no pain will be scored as zero and score 10 is for the highest pain.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactCyrus Emir Alavi

Rasht University of Medical Sciences

cyrusemiralavi@yahoo.com+98 13 3354 2460

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026