evaluation of applying Plasma rich growth factor(PRGF) with Metformin gel 1% in treating periodontal intrabony defects

Clinical and radiographic evaluation of applying Plasma rich growth factor(PRGF) with Metformin gel 1% in treating periodontal two-walls intrabony defects

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20100427003813N6

Enrollment

Registered

2018-05-10

Start date

2017-04-20

Completion date

Unknown

Last updated

2018-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic periodontitis.

Interventions

Intervention 1: interventional group:open flap debridement with metformin gel 1%. Intervention 2: Intervention group 2: open flap debridement with plasma-rich growth factor. Intervention 3: Intervent

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: At least 18 years old Chronic periodontal diseas with with two wall intabony defects Similar plaque index(under 15%) ??Ability to maintaing oral hygiene Signing of consenting form

Exclusion criteria

Exclusion criteria: Pregnancy Existing of coagulation problems use of drugs which interact with platellet use of drugs which interact with wound healing Allergy to surgical materials Infective disease( Hepatitis, AIDS, Tuberclosis) Any topical or systemic disease which containdicated to periodontal treatment

Design outcomes

Primary

Measure	Time frame
Radiologic outcomes. Timepoint: at the beginning of study and 6 months after study. Method of measurement: parallel technic by means of digital sensor size 2(Soredex.Helsinki-finland)by Rinndentsply film holder.;Vertical clinical attachment level. Timepoint: at the begining of study and immediately before surgery, 3 and 6 months after sergury. Method of measurement: with perodontal probe.;Gingival index. Timepoint: at the beginning of study, immediately before sugery. Method of measurement: absevational (sillness & Loe).;VPD(vertical probing depth). Timepoint: at the beginning of study, immediately before sugery. Method of measurement: with perodontal probe.	—

Measure

Time frame

Radiologic outcomes. Timepoint: at the beginning of study and 6 months after study. Method of measurement: parallel technic by means of digital sensor size 2(Soredex.Helsinki-finland)by Rinndentsply film holder.;Vertical clinical attachment level. Timepoint: at the begining of study and immediately before surgery, 3 and 6 months after sergury. Method of measurement: with perodontal probe.;Gingival index. Timepoint: at the beginning of study, immediately before sugery. Method of measurement: absevational (sillness & Loe).;VPD(vertical probing depth). Timepoint: at the beginning of study, immediately before sugery. Method of measurement: with perodontal probe.

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Countries

Iran (Islamic Republic of)

Contacts

Public Contact?????? ???????

Babol University of Medical Sciences

n.jenabian@mubabol.ac.ir+98 11 3220 7918

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026