Eeffect of oral administration of N- acetyl cysteine in Women with Endometriosis

Eeffect of oral administration of N- acetyl cysteine on decrease of oxidative stress , Concentration of heavy metals and lipid profile in Women with Endometriosis

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20100411003684N9

Enrollment

Registered

2020-01-27

Start date

2019-09-22

Completion date

Unknown

Last updated

2020-06-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endometriosis. Other endometriosis

Interventions

Intervention 1: Oral administration of N- acetyl cysteine with dose of 1/8 gr/day (overweight women 3 gr/day) during 6 weeks in addition to routine medication in women with endometriosis. Intervention

Eligibility

Sex/Gender

Female

Age

20 Years to 35 Years

Inclusion criteria

Inclusion criteria: Women with endometriosis ?Age 20-35 years old Laparoscopic diagnosis of endometriosis Not taking antioxidant supplements Lack of chronic diseases such as: diabetes- hepatitis- thalassemia anemia-infectious and inflammatory diseases No clinical or surgical treatment for the past six months Lack of polycystic ovary

Exclusion criteria

Exclusion criteria: Non-use of medication Thalassemia. Diabetes- Hepatitis- Anemia-Infectious and Inflammatory diseases.

Design outcomes

Primary

Measure	Time frame
Malondialdehyde (MDA). Timepoint: 6 Weeks. Method of measurement: TBARS Method (Spectrophotometry).;Total antioxidant capacity (TAC). Timepoint: 6 Weeks. Method of measurement: FRAP Method.;Blood Iron. Timepoint: 6 Weeks. Method of measurement: Spectrophotometry.;Lactate dehydrogenase (LDH). Timepoint: 6 Weeks. Method of measurement: Spectrophotometry.;8-OH-2-deoxy-Guanosine (8-OHdG). Timepoint: 6 Weeks. Method of measurement: ELISA.;Carbonyl. Timepoint: 6 Weeks. Method of measurement: Levin Method.;DPPH index. Timepoint: 6 Weeks. Method of measurement: Spectrophotometry.	—

Measure

Time frame

Malondialdehyde (MDA). Timepoint: 6 Weeks. Method of measurement: TBARS Method (Spectrophotometry).;Total antioxidant capacity (TAC). Timepoint: 6 Weeks. Method of measurement: FRAP Method.;Blood Iron. Timepoint: 6 Weeks. Method of measurement: Spectrophotometry.;Lactate dehydrogenase (LDH). Timepoint: 6 Weeks. Method of measurement: Spectrophotometry.;8-OH-2-deoxy-Guanosine (8-OHdG). Timepoint: 6 Weeks. Method of measurement: ELISA.;Carbonyl. Timepoint: 6 Weeks. Method of measurement: Levin Method.;DPPH index. Timepoint: 6 Weeks. Method of measurement: Spectrophotometry.

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Secondary

Measure	Time frame
Levels of Lead. Timepoint: 6 week. Method of measurement: Atomic absorption.;Levels of cadmium. Timepoint: 6 Week. Method of measurement: Atomic absorption.;Levels of nickel. Timepoint: 6 Week. Method of measurement: Atomic absorption.;Levels of chromium. Timepoint: 6 Week. Method of measurement: Atomic absorption.;Levels of High Density Lipoprotein (HDL). Timepoint: 6 Week. Method of measurement: Spectrophotometer.;Levels of Low Density Lipoprotein (LDL). Timepoint: 6 Week. Method of measurement: Spectrophotometer.;Levels of Triglyceride. Timepoint: 6 Week. Method of measurement: Spectrophotometer.;Levels of Cholesterol. Timepoint: 6 Week. Method of measurement: Spectrophotometer.;Levels of Cu. Timepoint: 6 Week. Method of measurement: Spectrophotometer.;Levels of Zn. Timepoint: 6 Week. Method of measurement: Spectrophotometer.;Levels of Zn. Timepoint: 6 Week. Method of measurement: Spectrophotometer.;Level of Carbonyl. Timepoint: 6 Week. Method of measurement: Spectrophotometer.;DPPH Index. Timepoint: 6 Week. Method of measurement: Spectrophotometer.	—

Measure

Time frame

Levels of Lead. Timepoint: 6 week. Method of measurement: Atomic absorption.;Levels of cadmium. Timepoint: 6 Week. Method of measurement: Atomic absorption.;Levels of nickel. Timepoint: 6 Week. Method of measurement: Atomic absorption.;Levels of chromium. Timepoint: 6 Week. Method of measurement: Atomic absorption.;Levels of High Density Lipoprotein (HDL). Timepoint: 6 Week. Method of measurement: Spectrophotometer.;Levels of Low Density Lipoprotein (LDL). Timepoint: 6 Week. Method of measurement: Spectrophotometer.;Levels of Triglyceride. Timepoint: 6 Week. Method of measurement: Spectrophotometer.;Levels of Cholesterol. Timepoint: 6 Week. Method of measurement: Spectrophotometer.;Levels of Cu. Timepoint: 6 Week. Method of measurement: Spectrophotometer.;Levels of Zn. Timepoint: 6 Week. Method of measurement: Spectrophotometer.;Levels of Zn. Timepoint: 6 Week. Method of measurement: Spectrophotometer.;Level of Carbonyl. Timepoint: 6 Week. Method of measurement: Spectrophotometer.;DPPH Index. Timepoint: 6 Week. Method of measurement: Spectrophotometer.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactProf. Soleiman Mahjoub

Babol University of Medical Sciences

smahjoub20@gmail.com+98 11 3219 0569

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026