subclinical hypothyroidism. Other hypothyroidism
Conditions
Interventions
Intervention 1: Intervention group: 50000 units weekly vitamin D of Zahravi company for 3 month. Intervention 2: Control group: Intake a Placebo perl containing sunflower oil, which is similar to vit
Sponsors
Tabriz University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
20 Years to 65 Years
Inclusion criteria
Inclusion criteria: Willingness to participate in research Women between the ages of 20 and 65 with subclinical hypothyroidism BMI 25-37 Kg / m2 TSH 5-10 micro units per milliliter and freeT3 and free T4 are normal
Exclusion criteria
Exclusion criteria: Serum Vitamin D Levels higher than 100 µg / L Smoking and alcohol Pregnancy and lactation Diabetes and infectious heart disease Kidney failure Cushing's syndrome Liver diseases Regular consumption of any dietary supplement during the last 2 months and during the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum Vitamin D. Timepoint: Baseline and 12 weeks after the intervention. Method of measurement: ELISA.;Glycemic indexes. Timepoint: Baseline and after 12 weeks after the intervention. Method of measurement: Glycemic indexes (from indicators of metabolic status) including fasting blood sugar by enzymatic method, insulin by ELISA and insulin resistance by formula, will be measured or calculated.;Lipid profile. Timepoint: Baseline and 12 weeks after the intervention. Method of measurement: Lipid profile ( from indicators of metabolic status) including total cholesterol, triglycerides and high-density lipoprotein will be measured enzymatically, and low-density lipoprotein will be calculated using the friedwald formula.;Thyroid hormones. Timepoint: Baseline and 12 weeks after the intervention. Method of measurement: Thyroid hormones including thyroid stimulating hormone, triiodothyronine and thyroxine will be measured by ELISA.;Irisin. Timepoint: Baseline and 12 weeks after the intervention. Method of measurement: ELISA. | — |
Secondary
| Measure | Time frame |
|---|---|
| Obesity indices. Timepoint: Baseline and 12 weeks after the intervention. Method of measurement: Obesity indices including weight with scales and waist circumference and hip circumference will be measured with a tape measure. Body mass index will be calculated with the formula.;Body composition. Timepoint: Baseline and 12 weeks after the intervention. Method of measurement: Body composition will be measured by Bio impedance (BIA) method usingTanita body composition analyzer.;Dietary intake. Timepoint: Baseline and 12 weeks after the intervention. Method of measurement: The food record questionnaire will be used to assess food intake including energy, carbohydrate, protein and fat.;Physical activity. Timepoint: Baseline and 12 weeks after the intervention. Method of measurement: The International Physical Activity Questionnaire will be used to measure physical activity. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSara Safari
Tabriz University of Medical Sciences
Outcome results
None listed