rheumatoid arthritis. Rheumatoid arthritis with rheumatoid factor
Conditions
Interventions
Intervention 1: Intervention group: 500 mg/day curcumin of karen company (1 capsule of 500 mg) after lunch for 2 month. Intervention 2: Control group: 500 mg/day placebo(1 capsule of 500mg containing
Sponsors
Tabriz University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
20 Years to 70 Years
Inclusion criteria
Inclusion criteria: The age range of 20-70 years in women Diagnosis of RA based on American College Rheumatology criteria and duration of more than one year Moderate RA (disease activity score 1.5-3.2) No infectious disease at least two weeks before study Body mass index less than 40 kilograms per square meters willingness to participate in the study.
Exclusion criteria
Exclusion criteria: Pregnant or lactating women those under hormone therapy or use of oral contraceptives suffering from cardiovascular disease, liver and kidney failure and inflammatory disease, diabetes and hypertension use of lipid and glycemic lower drugs and anticoagulant drugs Changes in medications during the study use of curcumin supplements and any antioxidant supplements in the last 2 months and during the study weight loss diet smoking
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum level of hs-CRP. Timepoint: Before the intervention and 8 weeks after starting. Method of measurement: ELISA.;Disease Activity Score28. Timepoint: Before the intervention and 8 weeks after starting. Method of measurement: Disease Activity Score 28 Questionnaire.;Serum level of visfatin. Timepoint: Before the intervention and 8 weeks after starting. Method of measurement: ELISA.;Serum level of ESR. Timepoint: Before the intervention and 8 weeks after starting. Method of measurement: Westergren.;Triglyceride. Timepoint: Before the intervention and 8 weeks after starting. Method of measurement: Enzymatic method.;Total cholesterol. Timepoint: Before the intervention and 8 weeks after starting. Method of measurement: Enzymatic method.;HDL-C. Timepoint: Before the intervention and 8 weeks after starting. Method of measurement: Enzymatic method.;LDL-C. Timepoint: Before the intervention and 8 weeks after starting. Method of measurement: Freidewald formula.;Fasting blood sugar. Timepoint: Before the intervention and 8 weeks after starting. Method of measurement: Enzymatic method.;Insulin. Timepoint: Before the intervention and 8 weeks after starting. Method of measurement: ELISA.;Insulin resistance. Timepoint: Before the intervention and 8 weeks after starting. Method of measurement: formula.;Total antioxidant capacity. Timepoint: Before the intervention and 8 weeks after starting. Method of measurement: Spectrophotometry.;Malondialdehyde. Timepoint: Before the intervention and 8 weeks after starting. Method of measurement: Spectrophotometry. | — |
Secondary
| Measure | Time frame |
|---|---|
| Anthropometric measurements (BMI, WHR, WC). Timepoint: Baseline and 8 weeks after the intervention. Method of measurement: Secca scale, non stretch meter.;Energy and nutrient intake. Timepoint: Baseline and 8 weeks after the intervention. Method of measurement: 24-hour dietary recall questionnaire for 3 days (two on week days and one on a weekend or holiday).;Physical activity. Timepoint: Baseline and 8 weeks after the intervention. Method of measurement: International Assessment of Physical Activity (IPAQ) questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFateme Pourhabibi
Tabriz University of Medical Sciences
Outcome results
None listed