Type 2 diabetes mellitus. Type 2 diabetes mellitus
Conditions
Interventions
Intervention 1: Intervention group: 54 mg/day genistein supplement in two capsule for 3 month. Intervention 2: Control group: 54 mg/day placebo in two capsule for 3 month.
Sponsors
Nutritional Reseach Center of Tabriz University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
45 Years to 67 Years
Inclusion criteria
Inclusion criteria: Willingness to participate in the study Postmenopausal women with history of at least one year menopause Type-2 diabetes for at least 6 months using blood glucose lowering drugs (metformin)
Exclusion criteria
Exclusion criteria: Unwillingness to participate in the study Surgery leads to menopause Early menopause (before 40 years) Use of androgen and estrogen and other steroids can affect the estrogen receptor Insulin injections Use of any nutritional supplements (omega-3) or anti-inflammatory and antioxidant supplements in the last 3 months or during the study Liver and kidney failure, cardiovascular disease, breast cancer and thyroid disease Smoking and alcohol Patients taking NSAID, corticosteroids (prednisone, methylprednisolone, and hydrocortisone), antidiuretic thiazide (furosemide and hydrochlorothiazide) and anti psychotics second generation (olanzapine, clozapine)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Homocysteine. Timepoint: Before the intervention and 12 weeks after starting. Method of measurement: ELISA.;PAI-1. Timepoint: Before the intervention and 12 weeks after starting. Method of measurement: ELISA. | — |
Secondary
| Measure | Time frame |
|---|---|
| Physical activity. Timepoint: Beginning and end of intervention. Method of measurement: International Assessment of Physical Activity (IPAQ) questionnaire.;Diet. Timepoint: First, middle and end of study. Method of measurement: 3-day food record. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public Contacthassan Braxas
Tabriz University of Medical Sciences
Outcome results
None listed