Affecting of vitamin D administration on mRNA expression of Treg/Th17 axis.

Treg/Th17 axis : the impact of vitamin D supplementation on TGF-ß and IL-17A balance and mRNA expression in Multiple Sclerosis patients compared to apparently healthy first degree relatives of patients and apparently healthy people.

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20100407003655N4

Enrollment

Registered

2018-11-02

Start date

2018-12-22

Completion date

Unknown

Last updated

2019-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multiple Sclerosis. Multiple sclerosis

Interventions

Intervention 1: Intervention group: . Intervention 2: Control group: .

Eligibility

Sex/Gender

All

Age

20 Years to 40 Years

Inclusion criteria

Inclusion criteria: The ability to give blood sample Tendency to take part in the study having 20-40 years old Verifying MS diseases by a neurologist expert No receiving of vitamin D supplementation in the last 2 months

Exclusion criteria

Exclusion criteria: Having malabsorption Consumption of medicine that interact with Vitamin D absorption Catching chronic and immune system diseases Consumption of Ca & Vitamin D supplementation pregnancy and lactation

Design outcomes

Primary

Measure	Time frame
IL-17A. Timepoint: Before and After supplementation. Method of measurement: Real time - PCR.;TGF-B. Timepoint: Before and After supplementation. Method of measurement: Real time - PCR.;Vitamin D. Timepoint: Before and After supplementation. Method of measurement: ECL.	—

Countries

Iran (Islamic Republic of)

Contacts

Public Contactseyed Rafie Arefhosseini

Tabriz University of Medical Sciences

arefhosseinir@tbzmed.ac.ir+98 41133575803

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026