Sepsis. Systemic Inflammatory Response Syndrome of infectious origin without organ failure
Conditions
Interventions
Intervention 1: Intervention group: Patients will receive placebo tablet (orally or though NG tube) once daily for 5-7 days along with supportive care, treatment of fluid and electrolyte disorders, m
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients over 18 years old with diagnosis of sepsis
Exclusion criteria
Exclusion criteria: Septic shock at the beginning of the study and the need for a vasopressor Conditions where colchicine interacts significantly with other medications Renal or liver failure Contraindications to colchicine History of allergic reactions to colchicine
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Efficacy of colchicine on the incidence of sepsis-induced organ failure. Timepoint: Daily for 5-7 days. Method of measurement: SOFA Score. | — |
Secondary
| Measure | Time frame |
|---|---|
| ICU admission requirement. Timepoint: Daily for 5-7 days. Method of measurement: Daily assessment.;Vasopressor requirement. Timepoint: Daily for 5-7 days. Method of measurement: Review of patients medications chart.;Corticosteroid requirement. Timepoint: Daily for 5-7 days. Method of measurement: Review of patients medications chart.;Respiratory support requirement. Timepoint: Daily for 5-7 days. Method of measurement: Review of patients medical records.;28-day mortality. Timepoint: 28 days after recruitment. Method of measurement: Medical records.;Length of ICU stay. Timepoint: Daily. Method of measurement: Medical records. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public Contact???? ?????
Tehran University of Medical Sciences
Outcome results
None listed