COVID-19 pneumonia. COVID-19, virus identified
Conditions
Interventions
Intervention 1: Intervention group: Concomitant with the standard of care, patients in group 1 will receive dexamethasone 4 mg IV BD for 7-10-days. Patients will be daily followed for response to the
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: Adult patients (18-85 years old) With diagnose of COVID-19 according to laboratory, clinical or radiological findings With indication for hospitalization
Exclusion criteria
Exclusion criteria: Contraindication of corticosteroids (uncontrolled diabetes mellitus, active bacteria, fungal or parasite infections, hypersensitivity reactions, close angle glaucoma, uncontrolled neuropsychiatric disorders, unstable cardiovascular disorders including acute myocardial infarction, acute thrombosis, uncontrolled hypertension, viral hepatitis, history of corticosteroids induced myopathy) Pregnancy Lactation History of recent corticosteroids or other immunosuppressant drugs use
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement of patients' chief complaint. Timepoint: Daily. Method of measurement: Clinical examination.;Improvement in peripheral blood oxygen saturation. Timepoint: Daily. Method of measurement: Pulse oximetry.;Decrease in serum CRP. Timepoint: Every other day. Method of measurement: Laboratory data.;Hyperglycemia. Timepoint: Daily. Method of measurement: Glucometer.;Changes in mood. Timepoint: Daily. Method of measurement: Psychiatric examination.;Myopathy. Timepoint: Daily. Method of measurement: Physical examination.;Secondary infections. Timepoint: Daily. Method of measurement: Clinical examination and laboratory parameters (CBC). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHossein Khalili
Tehran University of Medical Sciences
Outcome results
None listed