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?Effect of sofosbuvir/ ledipasvir on COVID-19

Evaluating efficacy and safety of sofosbuvir/ ledipasvir in treatment of COVID-19

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20100228003449N29
Enrollment
50
Registered
2020-03-19
Start date
2020-03-18
Completion date
Unknown
Last updated
2020-04-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19 pneumonia.

Interventions

Intervention 1: Intervention group: Concomitant with the national corona treatment recommendation (Tab hydroxychloroquine 400 mg twice daily at day 1 then 200 mg twice daily plus Tab lopinavir/ritonav

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Patients with highly suspected diagnosis of COVID-19 Patients with confirmed diagnosis of COVID-19 Patients who are candid for hospitalization Patients who are candid for starting triple-drug combination

Exclusion criteria

Exclusion criteria: History of drug allergy Pregnancy Lactation

Design outcomes

Primary

MeasureTime frame
Response to the treatment (improvement of patients' chief complaint, abnormal paraclinic and radiologic findings). Timepoint: Daily. Method of measurement: According the clinical, paraclinical and laboratory findings.;Gastrointestinal complications. Timepoint: Daily. Method of measurement: Interview and patient's record.;Cutaneous complications. Timepoint: Daily. Method of measurement: Interview and patient's record.;Neurological complications. Timepoint: Daily. Method of measurement: Interview and patient's record.;Renal complications. Timepoint: Daily. Method of measurement: Interview and patient's record.;Hematological complications. Timepoint: Daily. Method of measurement: Interview and patient's record.

Secondary

MeasureTime frame
Duration of hospitalization. Timepoint: End of the treatment. Method of measurement: Patient's record.;Clinical outcome (cure or death). Timepoint: End of treatment. Method of measurement: Patient's record.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHossein Khalili

Tehran University of Medical Sciences

khalilih@tums.ac.ir+98 21 6695 4715

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026