Optimizing vancomycin dosing in septic patients

Evaluating effect of optimizing vancomycin dosing according to AUC/MIC on systemic inflammatory responses syndrome (SIRS) in septic patients

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20100228003449N24

Enrollment

Registered

2018-07-21

Start date

2018-07-23

Completion date

Unknown

Last updated

2018-09-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis. Sepsis, unspecified

Interventions

Intervention 1: Vancomycin dosing according to AUC/MIC index. Intervention 2: Vancomycin dosing according to serum trough level.

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Patients with sepsis Patients with augmented renal clearance Patients with vancomycin indication Serum creatinine less than 1.3 mg/dl

Exclusion criteria

Exclusion criteria: Age less than 18 years old and more than 75 years old Receiving concomitant nephrotoxic agents Pregnancy Patients with vancomycin contraindications

Design outcomes

Secondary

Measure	Time frame
Vancomycin induced nephrotoxicity. Timepoint: Daily measurement of serum creatinine. Method of measurement: 0.5 mg/dl or 50% increase in serum creatinine from the baseline value.	—

Primary

Measure	Time frame
Access vancomycin target concentration. Timepoint: Days 2-5. Method of measurement: Chemiluminescent immunoassay (CLIA).;Clearance of systemic inflammatory response syndrome. Timepoint: Daily. Method of measurement: Evaluating vital signs, hemodynamic parameters and laboratory tests.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHossein khalili afousi

Tehran University of Medical Sciences

khalilih@tums.ac.ir+98 21 6658 1598

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026