Evaluation of Platanus orientalis L. distillate effects on allergic rhinitis

The clinical efficacy of Platanus orientalis L. distillate, as nasal drop, in allergic rhinitis- a pilot, randomized, double-blind, placebo-controlled clinical trial

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

IRCT

Registry ID

IRCT20100218003361N2

Enrollment

Registered

2018-12-30

Start date

2018-12-19

Completion date

Unknown

Last updated

2019-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Allergic rhinitis. Allergic rhinitis, unspecified

Interventions

Intervention 1: Intervention group: Platanus Orientalis L. distillate, prepared as nasal drop. It is applied 4 times a day for one month. Distillate is prepared in research center and is filled in the

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients aged 18-65 years Obtaining the informed consent Fulfillment of allergic rhinitis diagnostic criteria and the history of allergic rhinitis for at least two consecutive years

Exclusion criteria

Exclusion criteria: Systemic corticosteroid therapy in the past three months Local corticosteroid therapy in the past fifteen days Pregnancy Breast feeding Females at age of fertility with no particular pregnancy prevention method

Design outcomes

Primary

Measure	Time frame
Allergic rhinitis symptom score (nose, eyes, respiratory). Timepoint: Daily. Method of measurement: Filling the daily symptom questionnaire and symptom scores by the patient.;Comparing the daily mean scores of allergic rhinitis. Timepoint: Day 1- Day 30. Method of measurement: Statistical analyses.;Quality of life score (regular activities, recreational activities, sleep). Timepoint: At enrollment, at days 14 and 30. Method of measurement: Quality of life scoring in quality of life questionnaire.;Observing the variations in the severity of allergic rhinitis symptoms. Timepoint: Day 30. Method of measurement: Clinician evaluations.	—

Measure

Time frame

Allergic rhinitis symptom score (nose, eyes, respiratory). Timepoint: Daily. Method of measurement: Filling the daily symptom questionnaire and symptom scores by the patient.;Comparing the daily mean scores of allergic rhinitis. Timepoint: Day 1- Day 30. Method of measurement: Statistical analyses.;Quality of life score (regular activities, recreational activities, sleep). Timepoint: At enrollment, at days 14 and 30. Method of measurement: Quality of life scoring in quality of life questionnaire.;Observing the variations in the severity of allergic rhinitis symptoms. Timepoint: Day 30. Method of measurement: Clinician evaluations.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr.Soheila Alyasin

Shiraz University of Medical Sciences

alyasins@sums.ac.ir+98 36122268

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026