Benign breast disease. Benign neoplasm of breast
Conditions
Interventions
Intervention 1: Intervention group:Consume one pearl of vitamin D3 50,000 IU per week for 8 weeks. Participants will be advised to maintain their usual lifestyle, including their habitual diet.All par
Sponsors
Tabriz University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
19 Years to 50 Years
Inclusion criteria
Inclusion criteria: Histopathological evidence of BBT (fibrocystic, fibroadenoma, etc.) Age between 19 and 50 years At least two years since diagnosis willingness to cooperate and complete the informed consent form Serum vitamin D deficiency (less than 20 ng/ml)
Exclusion criteria
Exclusion criteria: Malabsorption disorders (such as Crohn's disease, celiac disease), biliary tract obstruction Acute or chronic conditions (including various types of cancer, liver, kidney, and acute heart failure), hyperthyroidism, hormonal disorders prior to diagnosis (e.g., polycystic ovary syndrome (PCOS)), type 1 diabetes, hypoglycemia, adrenal gland disorders Grade 3 obesity A daily calorie intake of less than 800 or more than 3500 kcal/d Asthma Any benign lesions in other organs Pregnancy Lactation Chemotherapy Radiotherapy Hormone therapy Cystectomy surgery Use of glucocorticoid, anti-seizure, contraceptive, and HRT medications Consuming more than 2000 mg of cod liver oil Taking painkillers containing caffeine
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VDR gene expression. Timepoint: Before the start of the intervention, 8 weeks after the start of the intervention (end of the intervention). Method of measurement: Real time RT-PCR.;Endocrine parameters. Timepoint: Before the start of the intervention, 8 weeks after the start of the intervention (end of the intervention). Method of measurement: ELIZA.;Metabolic parameters. Timepoint: Before the start of the intervention, 8 weeks after the start of the intervention (end of the intervention). Method of measurement: Enzymatic kits.;Adipokines. Timepoint: Before the start of the intervention, 8 weeks after the start of the intervention (end of the intervention). Method of measurement: ELIZA. | — |
Secondary
| Measure | Time frame |
|---|---|
| Nutritional status. Timepoint: Before the start of the intervention, 8 weeks after the start of the intervention (end of the intervention). Method of measurement: A 24-hour dietary recall in three days (one holiday and two working days) and valid food frequency questionnaire.;Physical activity. Timepoint: Before the start of the intervention, 8 weeks after the start of the intervention (end of the intervention). Method of measurement: Physical activity questionnaire.;Anthropometric status. Timepoint: Before the start of the intervention, 8 weeks after the start of the intervention (end of the intervention). Method of measurement: Centimeter, Scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Mehrangiz Ebrahimi- Mameghani
Tabriz University of Medical Sciences
Outcome results
None listed