Non-alcoholic fatty live. Fatty (change of) liver, not elsewhere classified
Conditions
Interventions
Intervention 1: Intervention group: Patients in this group will receive a weight loss diet with propolis supplement (3 capsules of 500 mg per day) after each meal for 8 weeks. This supplement is provi
Sponsors
Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 50 Years
Inclusion criteria
Inclusion criteria: NAFLD (Grade 1 and 2) Age 20-50 years Body mass index(BMI) in the range of 30-40 Kg / m2 Willingness to participate in the study
Exclusion criteria
Exclusion criteria: Pregnancy, lactation and menopause in women Smoking and alcohol use Skin or gastrointestinal allergies to propolis, honey and any of the beehive products Adherence to a special diet three months before the study Consumption of chemical or herbal medicines for weight loss Taking antibiotics or various supplements that affect the levels of liver enzymes Performing weight loss surgery in the last year or strict weight loss diets in the last three months Suffering from any conditions affecting liver function Use of hepatotoxic medications Taking multivitamins or antioxidant supplements during the last 3 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pro-Oxidant Antioxidant Balance (PAB). Timepoint: Baseline and 8 weeks after intervention. Method of measurement: Enzymatic_ colorimetric method and read it through ELISA.;Glutathione peroxidase(GPX). Timepoint: Baseline and 8 weeks after intervention. Method of measurement: Spectrophotometric method.;Superoxide dismutase (SOD). Timepoint: Baseline and 8 weeks after intervention. Method of measurement: Spectrophotometric method.;Malondialdehyde (MDA). Timepoint: Baseline and 8 weeks after intervention. Method of measurement: Spectrophotometric method.;Total Antioxidant Capacity (TAC). Timepoint: Baseline and 8 weeks after intervention. Method of measurement: Spectrophotometric method.;Fat mass. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: Using bioelectric impedance analyzer.;Free fat mass. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: Using bioelectric impedance analyzer.;Body water. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: Using bioelectric impedance analyzer.;Intake of energy, macronutrients and antioxidant micronutrients. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: The intake by 3-days food record form and analysis using nutritionist 4 software.;Alanine aminotransferase. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: Enzymatic method.;Aspartate aminotransferase. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: Enzymatic method.;Gamma Glutamyl transferase. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: Enzymatic method.;Fatty liver grade. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: Ultrasound findings.;Liver fibrosis score. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: Liver fibrosis score formula. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Mehrangiz Ebrahimimamagani
Tabriz University of Medical Sciences
Outcome results
None listed