The effect of DASH diet on NAFLD

The effect of weight loss diet based on DASH diet on proxidant-antioxidant balance levels, lipid profile, liver fibrosis score, appetite status and quality of life in patients with non-alcoholic fatty liver

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20100209003320N19

Enrollment

Registered

2021-06-06

Start date

2021-06-07

Completion date

Unknown

Last updated

2021-06-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-alcoholic fatty liver disease. Fatty (change of) liver, not elsewhere classified

Interventions

Intervention 1: Intervention group: Patients in this group will receive the DASH-based weight loss diet for 8 weeks. Intervention 2: Control group: Patients in this group will receive the usual weigh

Eligibility

Sex/Gender

All

Age

20 Years to 50 Years

Inclusion criteria

Inclusion criteria: Ages 20-50 Grade 1 and 2 NAFLD disease Body mass index in the range of 30-40 Kg / m2 Willingness to cooperate

Exclusion criteria

Exclusion criteria: Alcohol consumption Pregnancy Lactation Menopause Being an athlete Having a weight loss diet 3 months before the study The use of lowering blood sugar, lipid drugs , antibiotics , corticosteroids and Antioxidant supplement Suffering from metabolic diseases inc. cardiovascular, renal, liver, thyroid, autoimmune diseases, kidney stone and cancers

Design outcomes

Primary

Measure	Time frame
Anthropometric Indices. Timepoint: Baseline and 8 weeks after the intervention. Method of measurement: Measing height and weight without shoes and with minimum clothes using Seca stadiometer. Waist and hip circumferences will be measured using a tape and then body mass index (BMI) will be estimated by dividing weight (kg) to height squared (m2).;Liver enzymes (ALT , AST ). Timepoint: Baseline and 8 weeks after intervention. Method of measurement: Enzymatic method.;Albumin. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: Enzymatic method.;Platelet count. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: cell counter.;Pro-Oxidant Antioxidant Balance (PAB). Timepoint: Baseline and 8 weeks after intervention. Method of measurement: ELISA.;Lipid profile. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: Enzymatic colorimetric method.;Liver fibrosis score. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: Liver fibrosis score formula.;Blood glucose. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: Enzymatic method.;Appetite status. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: Validated appetite questionnaire.;Quality of life. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: Quality of Life Questionnaire.;Energy and macronutrients intakes. Timepoint: Baseline and 8 weeks after the intervention. Method of measurement: The intake of energy and macronutrients of the subjects using a 3-day food record questionnaire analyzed by the nutritionist 4 software.	—

Measure

Time frame

Anthropometric Indices. Timepoint: Baseline and 8 weeks after the intervention. Method of measurement: Measing height and weight without shoes and with minimum clothes using Seca stadiometer. Waist and hip circumferences will be measured using a tape and then body mass index (BMI) will be estimated by dividing weight (kg) to height squared (m2).;Liver enzymes (ALT , AST ). Timepoint: Baseline and 8 weeks after intervention. Method of measurement: Enzymatic method.;Albumin. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: Enzymatic method.;Platelet count. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: cell counter.;Pro-Oxidant Antioxidant Balance (PAB). Timepoint: Baseline and 8 weeks after intervention. Method of measurement: ELISA.;Lipid profile. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: Enzymatic colorimetric method.;Liver fibrosis score. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: Liver fibrosis score formula.;Blood glucose. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: Enzymatic method.;Appetite status. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: Validated appetite questionnaire.;Quality of life. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: Quality of Life Questionnaire.;Energy and macronutrients intakes. Timepoint: Baseline and 8 weeks after the intervention. Method of measurement: The intake of energy and macronutrients of the subjects using a 3-day food record questionnaire analyzed by the nutritionist 4 software.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactTaghi Badali

Tabriz University of Medical Sciences

Tbadali17@gmail.com+98 41 3335 7582

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026