Parkinson's Disease. Parkinson's disease
Conditions
Interventions
Intervention 1: Intervention group: injection of diluted Botulinum toxin in the affected hand muscles in addition to Parkinson's routine oral medicine.According to studies conducted so far, 7 muscles
Sponsors
Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
30 Years to 85 Years
Inclusion criteria
Inclusion criteria: Patients with idiopathic or familial Parkinson's disease (Parkinson's disease or PD); age between 30 to 85 years, one year after definitive diagnosis; patients with PD who have hand tremor (single-sided or bilateral). Patients with PD who are in stages I-III of Hoehn & Yahr staging . Patients with PD who are being treated with routine anti-Parkinson drugs, especially levodopa. Patients with PD who are willing to participate in the study and are satisfied with botulinum toxin injections.
Exclusion criteria
Exclusion criteria: Patients with PD who have had cognitive impairment or psychosis Patients with PD who have had a history of botulinum Toxin injection or any other injection over the past four months Patients with PD who have had a history of surgery (DBS: deep brain stimulation) Patients with secondary Parkinsonism, such as Pharmaceutical Parkinsonism Patients with hand tremor which is resulting from a medical condition, such as antipsychotic drugs Pregnancy and breastfeeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical severity of hand tremor. Timepoint: At the beginning of the study and before the intervention, 1.5 months, 4 months after injection. Method of measurement: 2 questionnaires including FTM (Fahn_Tolosa_Marin Temor Rating Scale) and UPDRS (Unified Parkinsone Disease Rating Scale). | — |
Secondary
| Measure | Time frame |
|---|---|
| Functional severity of hand tremor. Timepoint: At the beginning of the study and before the intervention, 1.5 months, 4 months after injection. Method of measurement: ADL questionnaire from Bain and Findley questionnaire, manual dynamometer, 10 euro coin test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Leila Fallah
Tabriz University of Medical Sciences
Outcome results
None listed