Condition 1: Women's sexual function. Condition 2: Depression. Decreased libido Major depressive disorder, single episode
Conditions
Interventions
Intervention 1: Intervention group: receiving L-arginine tablets (produced by Jalinous Pharmaceutical Company) 2 grams per day for 8 weeks. Intervention 2: Placebo group: receiving placebo tablets (pr
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Patients in the age group of 18-60 years. Patients are referred to the psychiatric clinic of Taleqani Hospital and Imam Hossein Hospital. Patients who are diagnosed with major depressive disorder by the DSM-5 diagnostic criteria. Patients who have the consent to enter the study and complete the consent form. Patients who have not had a history of taking an antidepressant in the past month before starting current medications. Patients who do not have autonomic disorders in the genital tract. Patients who can take oral medications and also likely to complete evaluations. Patients without active ulcers in the gastrointestinal tract. People entering the study must be married during the study period.
Exclusion criteria
Exclusion criteria: Patients who have impaired blood pressure regulation and are taking nitrate-based medications. Patients with diabetes mellitus Patients are taking potassium-sparing drugs. Patients are taking drugs that affect sexual dysfunction and improvement. Patients who have recently had a heart attack. Diagnosis of other psychological disorders along with the diagnosis of major depressive disorder or depression with anxiety in the patient. Consumption of alcohol or drugs or stimulants. Women who are in a menopausal state when starting the study. Lack of access or possibility of sexual intercourse with the husband during the study period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sexual function of women. Timepoint: Four weeks before the intervention; Zero, four, and eight weeks after receiving L-arginine. Method of measurement: Rosen et al. questionnaire was used to assess sexual satisfaction for women. | — |
Secondary
| Measure | Time frame |
|---|---|
| Side effects caused by using L-arginine. Timepoint: In two time periods of four and eight weeks after receiving L-arginine. Method of measurement: The patient complaint, clinical evidence, and symptoms.;Depression. Timepoint: In three time periods of zero, four and eight weeks after receiving L-arginine. Method of measurement: Hamilton questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMaria Tavakoli Ardakani
Shahid Beheshti University of Medical Sciences
Outcome results
None listed