Assesment of topical dexmedetomidine administration on intraoperative bleeding during functional endoscopic sinus surgery

Assesment of topical dexmedetomidine administration on intraoperative bleeding and quality of the surgical field during functional endoscopic sinus surgery in patients with chronic rhinosinusitis

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20100126003186N12

Enrollment

Registered

2019-09-24

Start date

2018-09-23

Completion date

Unknown

Last updated

2019-11-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic rhinosinusitis. Chronic pansinusitis

Interventions

Intervention 1: Intervention group: 2 microgram / kg dexmedetomidine which reached to 2 Ml with normal saline will be instilled into both nostrils, twenty minutes before surgery.(1 Ml to each nostril)

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Patients with chronic rhinosinusitis with or without polyposis candidate for FESS surgery Age between 18 and 60 years Lack of history of bleeding disorders such as hemophilia and ... and the disruptions of coagulation tests (PT, PTT, INR, BT, CT and platelet counts)

Exclusion criteria

Exclusion criteria: Allergy to dexmedetomidine Detection of complications during surgery or anesthesia requiring special action Patients with sinonasal tumors history of thromboembolic events history of acute or chronic renal failure take of anti-coagulant drugs for up to five days before surgery hepatic cirrhosis systemic diseases such as hypertension, diabetes, heart failure, cardiac rhythm disorders, and coronary artery disease pregnancy

Design outcomes

Primary

Measure	Time frame
Quality of surgical field. Timepoint: 15th, 30th, 60th and 90th minutes after surgery. Method of measurement: The quality of vision of surgical field was measured based on Boezaart Grading.;Amount of bleeding during surgery. Timepoint: 15th, 30th, 60th and 90th minutes after surgery. Method of measurement: the amount of intraoperative bleeding, based on the amount of blood collected in the bottle of suction will be estimated.	—

Measure

Time frame

Quality of surgical field. Timepoint: 15th, 30th, 60th and 90th minutes after surgery. Method of measurement: The quality of vision of surgical field was measured based on Boezaart Grading.;Amount of bleeding during surgery. Timepoint: 15th, 30th, 60th and 90th minutes after surgery. Method of measurement: the amount of intraoperative bleeding, based on the amount of blood collected in the bottle of suction will be estimated.

—

Secondary

Measure	Time frame
The amount of pain. Timepoint: 12 and 24 hours after surgery. Method of measurement: Visual Analogue Scale.;Median arterial pressure. Timepoint: 15th, 30th, 60th and 90th minutes after surgery. Method of measurement: using automated sphygmomanometer.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr farnaz Hashemian

Hamedan University of Medical Sciences

farnazhashemian@yahoo.com+98 81 3264 0051

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026