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Effect of Riluzole on Alzheimer's Disease

Effect of Riluzole on cognitive function of patients with mild Alzheimers disease: a double-blind randomized clinical trial, placebo-controlled

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20100126003181N4
Enrollment
48
Registered
2018-03-01
Start date
2018-04-21
Completion date
Unknown
Last updated
2018-03-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alzheimer Disease. Alzheimer's disease

Interventions

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
60 Years to 80 Years

Inclusion criteria

Inclusion criteria: Having of mild type of Alzheimer's Disease Receiving one of the anticholinesterase drugs for treating Alzheimer's from three months ago aged between 60-80

Exclusion criteria

Exclusion criteria: Having any other type of Dementia Any history of using Memantine or Riluzole History of using medications with glutamatergic interaction History of alcohol and opium abuse History of diseases such as Parkinson's disease, epilepsy, stroke, high blood pressure, uncontrolled diabetes, MS, mental retardation, CNS tumors, Huntington, subdural Hematoma, history of major psychiatric diseases History of severe head trauma that results in loss of consciousness

Design outcomes

Primary

MeasureTime frame
Cognitive function assessment. Timepoint: The first day and the 90th day of study. Method of measurement: Using the test of Mini Mental State Examination (MMSE).;Assessment of memory. Timepoint: The first day and the 90th day of study. Method of measurement: Using the test of Delayed recall test.;Assessment of disease progression. Timepoint: The first day and the 90th day of study. Method of measurement: Using the Functional Assessment Staging Tool (FAST).

Secondary

MeasureTime frame
Drug side effect. Timepoint: fourth week. Method of measurement: ask from patient.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr.Zahra Mokhtari

Tehran University of Medical Sciences

zmokhtari@razi.tums.ac.ir+98 21 6676 0269

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026