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The effect of topical application of bitter almond oil on the severity of neuropathic pain in patients undergoing chemotherapy

The effect of topical application of bitter almond oil on the severity of neuropathic pain in patients undergoing chemotherapy

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20100124003146N14
Enrollment
72
Registered
2025-06-20
Start date
2025-06-22
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neuropathic pain.

Interventions

Intervention 1: Intervention group: Participants in the intervention group will apply 5 cc of bitter almond oil to their hands up to the elbows and 5 cc to their legs up to the knees three times a da

Sponsors

Kashan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Willingness to participate in the research Patients undergoing chemotherapy with platinum compounds (cisplatin, oxaliplatin, carboplatin) or taxanes (paclitaxel, docetaxel) or vinca alkaloids (vincristine, vinblastine) DN4 score equal to or greater than 4 No cognitive problems based on the AMT questionnaire score greater than 8 No psychiatric disorders based on self-report from the patient and accompanying person No disabilities or movement disorders Ability to speak Persian No history of type 1 or type 2 diabetes based on self-report from the patient No history of allergy to topical oils and aromatherapy essences based on self-report from the patient

Exclusion criteria

Exclusion criteria: Lack of willingness to continue participation in the research Death or unavailability of the participant Patients with metastasis to soft tissue and bone Not taking medication for 3 consecutive days Development of local allergies or wounds at the intervention site Hospitalization Self-medication with supplements (outside of doctor's orders) for the management of neuropathic pain

Design outcomes

Primary

MeasureTime frame
Consequences of neuropathic pain. Timepoint: At the beginning of the study (before the start of the intervention), Day 15 of intervention, the end of the intervention (30 days), one month after the end of the intervention. Method of measurement: Douleur Neuropathique 4 Questionnaire.

Secondary

MeasureTime frame
Quality of life. Timepoint: At the beginning of the study (before the start of the intervention), Day 15 of intervention, the end of the intervention (30 days), one month after the end of the intervention. Method of measurement: The European organization for research and treatment of cancer quality of life questionnaire–Chemotherapy-Induced Peripheral Neuropathy 20-Item Scale.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactIsmail Azizi-Fini

Kashan University of Medical Sciences

azizifinies@yahoo.com+98 36 155103136

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 7, 2026