Evaluating the effects of Lactobacillus acidophilus (Johnsonii) La?, as a postbiotic supplementation, on the prevention of antibiotic associated diarrhoea and associated gastrointestinal symptom. Allergic and dietetic gastroenteritis and colitis
Conditions
Interventions
Intervention 1: Intervention group: All participants will receive a capsule of postbiotic twice daily during the antibiotic treatment and a week afterward, scheduled 2 to 3 hours apart from antibiotic
Sponsors
Islamic Azad University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Patients aged 18 to 75 years who are currently receiving systemic antibiotic therapy, agree to comply with the study protocol, and sign the informed consent form after being fully informed about all potential benefits and risks of the study.
Exclusion criteria
Exclusion criteria: Lack of willingness to continue participation in the study; patients with abnormal colonoscopy findings; presence of tumors, colorectal cancer, malignancy or history of malignancy; post-gastrectomy or enterectomy; chronic gastrointestinal diseases such as Crohn’s disease or ulcerative colitis; chronic pancreatitis; short bowel syndrome; diagnosed immunodeficiency caused by any chronic disease; bloody diarrhea or severe dehydration; human immunodeficiency virus (HIV); autoimmune disorders; women who are pregnant, breastfeeding, or planning to become pregnant during the study period; history of substance abuse including addiction to drugs or alcohol; lactose intolerance; use of any immunosuppressive or immunomodulatory drugs; use of other bioactive products such as probiotics, postbiotics, or similar products during the study; and patients with known allergic reactions to the investigational product or its related components.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Daily Bowel movements frequency. Timepoint: Every 3 days (3days ± 2 days). Method of measurement: Validated questionnaire based on WHO.;Stool consistency. Timepoint: Every 3 days (3days ± 2 days). Method of measurement: Validated questionnaire based on Bristol Scale Score. | — |
Secondary
| Measure | Time frame |
|---|---|
| Associated gastrointestinal symptoms. Timepoint: Every 3days (3days ± 2days). Method of measurement: Validated questionnaire based on the Gastrointestinal Symptom Rating Scale (GSRS) scoring system. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSeyedehSayeh Marashi
Islamic Azad University
Outcome results
None listed