Effect of Simvastatin gel in treatment of acne

Comparison of the Efficacy and Safety of Simvastatin 2% Topical Gel with Placebo in Treatment of Acne Vulgaris Patients

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20100119003106N38

Enrollment

Registered

2018-07-28

Start date

2018-07-15

Completion date

Unknown

Last updated

2018-09-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acne Vulgaris. Acne vulgaris

Interventions

Intervention 1: Intervention group: the use of gel simvastatin 2% on half of the face twice a day for 8 weeks. Intervention 2: Control group: the use of gel placebo on half of the face twice a day for

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with mild and moderate acne vulgaris

Exclusion criteria

Exclusion criteria: Pregnant women Breastfeeding women The patients with dermatological malignancy The patients with burning The patients with infection The patients which have known hypersensitivity to simvastatin The patients which have received any topical or oral medications for acne vulgaris in the last one month

Design outcomes

Primary

Measure	Time frame
Acne scores in the Global Acne Grading System. Timepoint: Before intervention and 2, 5 , 8 weeks after intervention. Method of measurement: The Global Acne Grading System Formula.	—

Secondary

Measure	Time frame
Quality of life score. Timepoint: Before intervention and 2, 5, 8 weeks after intervention. Method of measurement: The Cardiff Acne Disability Index questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mehdi Rajabi

Islamic Azad University

mehdirj@aol.com+98 21 2264 0051

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026