Major Depressive Disorder. Major depressive disorder, single episode, unspecified
Conditions
Interventions
Intervention 1: Intervention group: Piracetam 800 mg tablets manufactured by Darou Pakhsh Pharmaceutical Company. One pill should be taken every 8 hours a day for 2 months. Pills should be swallowed c
Sponsors
Islamic Azad University
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Patients experiencing first episodes of depression according to DSM-V criteria whose Hamilton's Depression Rating Scale scores were ranged from 18 to 36. Being drug-naïve to antidepressant treatments.
Exclusion criteria
Exclusion criteria: History of being on antidepressant medication. History of having psychiatric disorders. Having significant suicidal ideation. Suffering from liver and kidney dysfunction and cardiovascular disorders. History of drug abuse. Pregnancy and lactation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of Depression in the patients. Timepoint: Before the intervention and 4 and 8 weeks after initiation of the intervention. Method of measurement: Hamilton's Depression Rating Scale (HDRS).;Serum levels of Interleukin_6. Timepoint: Before the intervention and 4 and 8 weeks after initiation of the intervention. Method of measurement: Enzyme_Linked Immunosorbent Assay (ELISA) test for Interleukin_6. | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of life. Timepoint: At the baseline, and 4 and 8 weeks following the interventions. Method of measurement: Questionnaire.;Possible side effects will be investigated as secondary outcome measures. Timepoint: At the baseline, and 4 and 8 weeks following the interventions. Method of measurement: Questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSeyyede Alaleh Hosseini
Islamic Azad University
Outcome results
None listed