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Evaluation of the effect of pretransplant, high-dose intravenous vitamin C in prevention of delayed graft function after deceased kidney transplantation

Evaluation of the effect of pretransplant, high-dose intravenous vitamin C in prevention of delayed graft function after deceased kidney transplantation

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20100111003043N13
Enrollment
50
Registered
2019-06-24
Start date
2019-06-20
Completion date
Unknown
Last updated
2019-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Complications of kidney transplant. Complications of kidney transplant

Interventions

Intervention 1: Intervention group: Patients in the treatment arm receive 70 mg/kg vitamin C (at least 3 grams) at last hour before transplant surgery. The calculated dose is diluted in 250 ml of sodi

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
14 Years to No maximum

Inclusion criteria

Inclusion criteria: First kidney transplantation Brain death donor Transplant recipient age 14 or more Patient informed consent to enter the study

Exclusion criteria

Exclusion criteria: Hemochromatosis ESRD due to hyperoxaluria Multi-organ transplantation Favism history Preemptive kidney transplantation

Design outcomes

Primary

MeasureTime frame
Dialysis in the first week after the kidney transplant. Timepoint: Daily in the first week after the kidney transplant. Method of measurement: Medical records review.;Serum creatinine. Timepoint: Daily in the first week after kidney transplant then monthly until three months. Method of measurement: Jaffe's reaction.;Urine volume in the first six hours after transplantation. Timepoint: The first six hours after transplantation. Method of measurement: Urine volume.

Secondary

MeasureTime frame
Acute rejection episode in the first three months after transplantation. Timepoint: the first three months after transplantation. Method of measurement: Medical records review.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMina Borran

Tehran University of Medical Sciences

mina.borran@gmail.com+98 21 6119 2085

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 18, 2026