Liver transplantation. Complications of transplanted organs and tissue
Conditions
Interventions
Intervention 1: L-Carnitine syrup 500 mg per 5 cc, 500 mg twice a day from the time of entry to the transplant waiting list up to the day of liver transplantation will be used. Intervention 2: Placebo
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
14 Years to 70 Years
Inclusion criteria
Inclusion criteria: All patients over 14 years old with liver cirrhosis who are candidate for the first liver transplantation on the liver transplant list of Imam Khomeini Hospital Complex Patient's consent to enter the study
Exclusion criteria
Exclusion criteria: Children under the age of 14 years who are candidate for liver transplantation Patients candidate for liver re-transplantation Patients who are candidate for liver transplant due to acute liver failure Patients undergoing simultaneous multiple organ transplantations (simultaneous liver-kidney transplantation, simultaneous liver-pancreas-kidney transplantation) Patients undergoing split liver transplantation from living donors or deceased donors Pregnant or lactating women History of allergy to L-Carnitine Patients with a history of seizure Patients with postoperative unstable conditions such as fever, sepsis, and shock, Cardiac instability (ACS/MI), gastrointestinal bleeding, long-term need for vasopressor (norepinephrine at doses greater than 0.5 µg/kg/min)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluation of the occurrence of primary graft non-function after liver transplantation. Timepoint: Daily within first week after liver transplantation. Method of measurement: Laboratory evaluation of liver function tests including international normalized ratio, serum aminotransferases, serum bilirubin, lactate concentration, blood glucose, venous or arterial blood pH.;Evaluation of the occurrence of initial graft poor function after liver transplantation. Timepoint: Daily within first week after liver transplantation. Method of measurement: Laboratory evaluation of liver function tests including international normalized ratio, serum aminotransferases, serum bilirubin, lactate concentration, blood glucose, venous or arterial blood pH. | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation of occurrence of kidney function after liver transplantation. Timepoint: Daily within first week after liver transplantation. Method of measurement: Urinary output measurement and laboratory assessment of serum creatinine concentration.;Evaluating length of ICU stay. Timepoint: Daily from ICU admission to ICU discharge. Method of measurement: Counting the days of ICU stay.;Evaluating length of hospital stay. Timepoint: Daily from transplant surgery to hospital discharge. Method of measurement: Counting the days of hospital stay. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactBehrooz Khajeh
Tehran University of Medical Sciences
Outcome results
None listed