Comparison of the effectiveness of Fentanyl-Propofol versus Fentanyl-Dexmedetomidine drug regimens on sedation and hemodynamic control in intubated septic patients: A clinical trial study

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20100107003014N28

Enrollment

Registered

2026-02-18

Start date

2025-12-06

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis. Other sepsis

Interventions

Intervention 1: Intervention group: The group receiving "fentanyl and propofol" receives fentanyl at 0.7-10µg/kg/h for pain control and propofol at 1mg/kg loading dose for 20 minutes for sedation and

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Intubated septic patients 18 year-old and older

Exclusion criteria

Exclusion criteria: Pregnancy or breastfeeding Blind or deaf 3rd or 4th degree heart block Permanent bradycardia Neuromuscular block for more than 48hours Allergy to dexmedetomidine, propofol or fentanyl Liver failure Renal failure Participating in any other clinical trial concomitantly Brain death Body mass index greater than 40 Allergy to soy or egg

Design outcomes

Primary

Measure	Time frame
Mean arterial pressure. Timepoint: Every one hour. Method of measurement: Via noninvasive cardiac monitoring.;Sedation and pain. Timepoint: Every eight hours. Method of measurement: Via RASS and CPOT scale.	—

Secondary

Measure	Time frame
Capillary refill time measurement. Timepoint: Baseline,6,24,48 and 72hourse after intensive care admission. Method of measurement: Chronometer.;Norepinephrine equivalent dose to mean arterial pressure ratio. Timepoint: Baseline and every 24hours. Method of measurement: Blood pressure monitoring device and intensive care unit daily sheet.;Significant Bradycardia. Timepoint: Every one houre. Method of measurement: Cardiac monitoring device.;Rapid shallow breathing index. Timepoint: Baseline and every eight hours. Method of measurement: Ventilator.;Arterial oxygen pressure to fraction of inspired oxygen. Timepoint: 2 hours after intubation and daily. Method of measurement: Ventilator and laboratory report.;Organs failure. Timepoint: Baseline and every eight hours. Method of measurement: Clinical assessment and laboratory report.;Glasgow coma scale score. Timepoint: Baseline and every eight hours. Method of measurement: Clinical assessment.;Amount of required opioid. Timepoint: Daily. Method of measurement: Intensive care unit sheet.	—

Measure

Time frame

Capillary refill time measurement. Timepoint: Baseline,6,24,48 and 72hourse after intensive care admission. Method of measurement: Chronometer.;Norepinephrine equivalent dose to mean arterial pressure ratio. Timepoint: Baseline and every 24hours. Method of measurement: Blood pressure monitoring device and intensive care unit daily sheet.;Significant Bradycardia. Timepoint: Every one houre. Method of measurement: Cardiac monitoring device.;Rapid shallow breathing index. Timepoint: Baseline and every eight hours. Method of measurement: Ventilator.;Arterial oxygen pressure to fraction of inspired oxygen. Timepoint: 2 hours after intubation and daily. Method of measurement: Ventilator and laboratory report.;Organs failure. Timepoint: Baseline and every eight hours. Method of measurement: Clinical assessment and laboratory report.;Glasgow coma scale score. Timepoint: Baseline and every eight hours. Method of measurement: Clinical assessment.;Amount of required opioid. Timepoint: Daily. Method of measurement: Intensive care unit sheet.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactShahram ala

Mazandaran University of Medical Sciences

sala@mazums.ac.ir+98 11 3354 3083

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026