Traumatic brain injury. Intracranial injury
Conditions
Interventions
Intervention 1: Intervention group1: 30 mg tablet Memantine , twice daily until one week. Intervention 2: Control group: Placebo, 30 mg tablet, twice daily until one week.
Sponsors
Mazandaran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Traumatic brain injury (TBI) Glasgow Coma Scale (GCS) between 6-12 Being at the age of 18 years old and above The patient can tolerate the drug in the first 24 hours after traumatic brain injury
Exclusion criteria
Exclusion criteria: Diabetes mellitus, uncontrolled (random blood sugar greater than 200 mg / dL at the time of administration) Acute myocardial infarction in the last 48 hours Acute or chronic renal failure, creatinine clearance less than 60 ml per minute Autoimmune disorders and malignant diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neuron-specific enzyme (NSE). Timepoint: Days 1, 3 and 7. Method of measurement: Laboratory test.;Glasgow coma scale. Timepoint: Days 1, 3 and 7. Method of measurement: clinical. | — |
Secondary
| Measure | Time frame |
|---|---|
| Survival / Death. Timepoint: 3 months later. Method of measurement: Phone call with patient. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactShahram Ala
Mazandaran University of Medical Sciences
Outcome results
None listed