effect of dexmedetomidine on the outcome of septic shock patients

Study of the effect of dexmetedomidine on the outcome of patients with septic shock admitted to the intensive care unit, a randomized single blind placebo controlled trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20100107003014N22

Enrollment

Registered

2019-02-25

Start date

2018-07-23

Completion date

Unknown

Last updated

2019-03-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Septic shock. Other shock

Interventions

Intervention 1: Intervention group: Dexmedetomidine 0.8 micro/kg/h for 12 hours. Intervention 2: Control group: Serum Normal saline 6 cc/kg/hr up to 12 hr.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients with septic shock patients treated with norepinephrine or vasopressor Patients over the age of 18 years

Exclusion criteria

Exclusion criteria: uncontrolled diabet melitus patients with severe hepatic failure hypovolemic patients patients with a history of beta blocker use patients with a history of COPD patients with sick sinus syndrome patients with heart block 2,3

Design outcomes

Primary

Measure	Time frame
Clinical success. Timepoint: Every hour to 12 hours and then 7 days after intervention. Method of measurement: Data collecting form.	—

Secondary

Measure	Time frame
Heart rate changes. Timepoint: Every hour up to 12 hours. Method of measurement: Recorder monitor.;Mean arterial pressure changes. Timepoint: Every hour up to 12 hours. Method of measurement: Recorder monitor.;Systolic blood pressure changes. Timepoint: Every hour up to 12 hours. Method of measurement: Recorder monitor.;Diastolic blood pressure changes. Timepoint: Every hour up to 12 hours. Method of measurement: Recorder monitor.;Norepinephrine dose. Timepoint: Every hour up to 12 hours. Method of measurement: Data collecting form.;Morphine dose. Timepoint: Every hour up to 12 hours. Method of measurement: Data collecting form.;Midazolam dose. Timepoint: Every hour up to 12 hours. Method of measurement: Data collecting form.;SOFA score. Timepoint: Prime of entrance and 7days later. Method of measurement: Data collecting form.;GCS. Timepoint: Prime of entrance. Method of measurement: Data collecting form.;APACHE II. Timepoint: Prime of entrance. Method of measurement: Data collecting form.;Delirium. Timepoint: Prime of entrance. Method of measurement: Data collecting form.;Dependence on ventilator. Timepoint: 7days after intervention. Method of measurement: Data collecting form.;Survival of patients. Timepoint: 7 days after intervention. Method of measurement: Data collecting form.	—

Measure

Time frame

Heart rate changes. Timepoint: Every hour up to 12 hours. Method of measurement: Recorder monitor.;Mean arterial pressure changes. Timepoint: Every hour up to 12 hours. Method of measurement: Recorder monitor.;Systolic blood pressure changes. Timepoint: Every hour up to 12 hours. Method of measurement: Recorder monitor.;Diastolic blood pressure changes. Timepoint: Every hour up to 12 hours. Method of measurement: Recorder monitor.;Norepinephrine dose. Timepoint: Every hour up to 12 hours. Method of measurement: Data collecting form.;Morphine dose. Timepoint: Every hour up to 12 hours. Method of measurement: Data collecting form.;Midazolam dose. Timepoint: Every hour up to 12 hours. Method of measurement: Data collecting form.;SOFA score. Timepoint: Prime of entrance and 7days later. Method of measurement: Data collecting form.;GCS. Timepoint: Prime of entrance. Method of measurement: Data collecting form.;APACHE II. Timepoint: Prime of entrance. Method of measurement: Data collecting form.;Delirium. Timepoint: Prime of entrance. Method of measurement: Data collecting form.;Dependence on ventilator. Timepoint: 7days after intervention. Method of measurement: Data collecting form.;Survival of patients. Timepoint: 7 days after intervention. Method of measurement: Data collecting form.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactShahram Ala

Sari University of Medical Sciences

sala@mazums.ac.ir+98 11 3354 3083

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026