Effect of hydroalcoholic extract of Ruscus hyrcanus in treatment of chronic venous insufficiency

Study of therapeutic effects of ointment containing hydro alcoholic extract of root and rhizome of Ruscus hyrcanus woronow in patients with chronic venous insufficiency (Varicos vein); a randomized, double blind, controlled with placebo.

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

IRCT

Registry ID

IRCT20100107003014N21

Enrollment

Registered

2018-12-06

Start date

2018-09-23

Completion date

Unknown

Last updated

2019-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Varicose vein of lower extremities. Asymptomatic varicose veins of lower extremities

Interventions

Intervention 1: Intervention group: Ruscus extract 2% ointment/ 2 times daily/ 1 cm of the ointment/ For one month. Intervention 2: Control group: ointment formolation without any drugs/ 1 cm of the o

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: at least 18 years old varicose grade C1, C2 and C3

Exclusion criteria

Exclusion criteria: History of allergic reactions to plants in this family Pregnancy and Lactation Uncontrolled Diabetes

Design outcomes

Primary

Measure	Time frame
The amount of pain and feet heaviness according to the questionnaire. Timepoint: Completion of the questionnaire and examination at the beginning of the study and 14 and 28 days after the start of the application of Ruscus ointment. Method of measurement: Aberdeen varicose vein questionnaire (AVVQ), Observation and examination.;Changes in the amount of swollen ankles according to the questionnaire. Timepoint: Completion of the questionnaire and examination at the beginning of the study and 14 and 28 days after the start of the application of Ruscus ointment. Method of measurement: Aberdeen varicose vein questionnaire (AVVQ), Observation and examination.;Variation of vascular changes in vascular area according to questionnaire. Timepoint: Completion of the questionnaire and examination at the beginning of the study and 14 and 28 days after the start of the application of Ruscus ointment. Method of measurement: Aberdeen varicose vein questionnaire (AVVQ), Observation and examination.	—

Measure

Time frame

The amount of pain and feet heaviness according to the questionnaire. Timepoint: Completion of the questionnaire and examination at the beginning of the study and 14 and 28 days after the start of the application of Ruscus ointment. Method of measurement: Aberdeen varicose vein questionnaire (AVVQ), Observation and examination.;Changes in the amount of swollen ankles according to the questionnaire. Timepoint: Completion of the questionnaire and examination at the beginning of the study and 14 and 28 days after the start of the application of Ruscus ointment. Method of measurement: Aberdeen varicose vein questionnaire (AVVQ), Observation and examination.;Variation of vascular changes in vascular area according to questionnaire. Timepoint: Completion of the questionnaire and examination at the beginning of the study and 14 and 28 days after the start of the application of Ruscus ointment. Method of measurement: Aberdeen varicose vein questionnaire (AVVQ), Observation and examination.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactEhsan seifi

Sari University of Medical Sciences

sala@mazums.ac.ir+98 11 3354 3083

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026