Effect of hydroalcoholic extract of Ruscus hyrcanus in treatment of chronic venous insufficiency

Study of therapeutic effects of ointment containing hydro alcoholic extract of root and rhizome of Ruscus hyrcanus woronow in patients with chronic venous insufficiency (Grade 1 and 2 hemorrhoids); a randomized, double blind, controlled with placebo study.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20100107003014N20

Enrollment

Registered

2018-10-28

Start date

2018-09-11

Completion date

Unknown

Last updated

2019-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Hemorrhoids grade 1. Condition 2: Hemorrhoids grade 2. First degree hemorrhoids Second degree hemorrhoids

Interventions

Intervention 1: Intervention group: Ruscus extract 2% ointment/ 2 times daily/ 1 cm of the ointment/ For one month. Intervention 2: Control group: ointment formolation without any drugs/ 1 cm of t

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: at least 18 years old first and second untreated hemorrhoids

Exclusion criteria

Exclusion criteria: History of allergic reactions to plants in this family Pregnancy and Lactation History of any anorectal surgery and non-pharmacological treatment of hemorrhoids Ascetic, IBD, Inflammation and any illness that causes rectal bleeding Thrombosis or external hypersensitivity of the hemorrhoid Fissure or anal fistula Hemorrhoids Grade 3 and 4 Anal abscess, port hypertension Renal failure and any malignancy

Design outcomes

Primary

Measure	Time frame
Permanent pain. Timepoint: Measuring the amount of pain at the beginning of the study, the first week, the second, third and fourth weeks after the start of the study, is evaluated and recorded. Method of measurement: Visual Analogue Scale.;Pain during defecation. Timepoint: Measuring the amount of pain at the beginning of the study, the first week, the second, third and fourth weeks after the start of the study, is evaluated and recorded. Method of measurement: Visual analogue Scale.;Anal bleeding. Timepoint: Measuring the amount of bleeding at the beginning of the study, the first week, the second, third and fourth weeks after the start of the study, is evaluated and recorded. Method of measurement: Visually and classified as: bloodless (0), low (1), moderate (2) and high (3).;Strain during defecation. Timepoint: Measuring the amount of strain at the beginning of the study, the first week, the second, third and fourth weeks after the start of the study, is evaluated and recorded. Method of measurement: Mental scaling: defecation without strain(0), low(1), intermediate(2), high (3).;Burning and itchy and unpleasant. Timepoint: Measuring the amount of Burning and itching at the beginning of the study, the first week, the second, third and fourth weeks after the start of the study, is evaluated and recorded. Method of measurement: Visual analogue Scale.	—

Measure

Time frame

Permanent pain. Timepoint: Measuring the amount of pain at the beginning of the study, the first week, the second, third and fourth weeks after the start of the study, is evaluated and recorded. Method of measurement: Visual Analogue Scale.;Pain during defecation. Timepoint: Measuring the amount of pain at the beginning of the study, the first week, the second, third and fourth weeks after the start of the study, is evaluated and recorded. Method of measurement: Visual analogue Scale.;Anal bleeding. Timepoint: Measuring the amount of bleeding at the beginning of the study, the first week, the second, third and fourth weeks after the start of the study, is evaluated and recorded. Method of measurement: Visually and classified as: bloodless (0), low (1), moderate (2) and high (3).;Strain during defecation. Timepoint: Measuring the amount of strain at the beginning of the study, the first week, the second, third and fourth weeks after the start of the study, is evaluated and recorded. Method of measurement: Mental scaling: defecation without strain(0), low(1), intermediate(2), high (3).;Burning and itchy and unpleasant. Timepoint: Measuring the amount of Burning and itching at the beginning of the study, the first week, the second, third and fourth weeks after the start of the study, is evaluated and recorded. Method of measurement: Visual analogue Scale.

—

Secondary

Measure	Time frame
Side effect during treatment. Timepoint: The type of side effect measured during treatment at the first, second, third and fourth week after the start of treatment. Method of measurement: observation and according to questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFateme Shamalizade Baii

Sari University of Medical Sciences

sala@mazums.ac.ir+98 11 3354 3083

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026