Comparison of the clinical effectiveness of the two different doses of Meropenem in pneumonia

Comparison of the clinical effectiveness of the two different doses of Meropenem in critically ill patients with hospital acquired or ventilator associated pneumonia: a randomized single-blind clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20100107003014N19

Enrollment

Registered

2018-04-27

Start date

2018-04-21

Completion date

Unknown

Last updated

2018-05-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bacterial pneumonia. Bacterial pneumonia, not elsewhere classified

Interventions

Intervention 1: Intervention group: Meropenem 3 gram every 8 hours, 3 hours extended infusion for 7 days. Intervention 2: Control group: Meropenem 2 gram every 8 hours, 3 hours extended infusion for

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Critically ill patients admitted to the intensive care unit Patients with hospital acquired or ventilator associated pneumonia Indication to receive Meropenem between 18 and 70 years old

Exclusion criteria

Exclusion criteria: Pregnant or breastfeeding women Acute or chronic renal failure Epilepsy or history of siezure CNS infection Immune-compromised or using immunomodulator agents Known allergy to carbapenems

Design outcomes

Primary

Measure	Time frame
Clinical success. Timepoint: 7 days after intervention. Method of measurement: Collecting data forum.	—

Secondary

Measure	Time frame
All-cause mortality. Timepoint: 7, 14 and 28 days after intervention. Method of measurement: Data collecting form.;Clinical success with modification. Timepoint: 7 and 14 days after intervention. Method of measurement: Data collecting form.;Time to weaning. Timepoint: 28 days. Method of measurement: Data collecting form.;Time to intensive care unit discharge. Timepoint: 28 days. Method of measurement: Data collecting form.;Time to hospital discharge. Timepoint: 28 days. Method of measurement: Data collecting form.	—

Measure

Time frame

All-cause mortality. Timepoint: 7, 14 and 28 days after intervention. Method of measurement: Data collecting form.;Clinical success with modification. Timepoint: 7 and 14 days after intervention. Method of measurement: Data collecting form.;Time to weaning. Timepoint: 28 days. Method of measurement: Data collecting form.;Time to intensive care unit discharge. Timepoint: 28 days. Method of measurement: Data collecting form.;Time to hospital discharge. Timepoint: 28 days. Method of measurement: Data collecting form.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactShahram Ala

Sari University of Medical Sciences

sala@mazums.ac.ir+98 11 3354 3083

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026