Effect of Hypertonic Saline on Hemodynamic Variables in Urologic Surgery with Spinal Anesthesia

Effect of Hypertonic Saline on Hemodynamic Variables in Patients Undergoing Urologic Surgery with Spinal Anesthesia

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20100102002963N41

Enrollment

Registered

2026-02-16

Start date

2026-02-19

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Hemodynamic Instability. Condition 2: Hemodynamic Instability. Condition 3: Hemodynamic Instability. Condition 4: Hyponatremia. Condition 5: Hypernatremia. Condition 6: Seizure. Condition 7: Altered Mental Status. Condition 8: Altered Mental Status. Shock, unspecified Hypotension, unspecified Syncope and collapse Hypo-osmolality and hyponatremia Hyperosmolality and hypernatremia Unspecified convulsions Altered mental status, unspecified Unspecified coma

Interventions

Intervention 1: Intervention group: The volume of infused fluid is calculated based on each patient’s body weight. The intervention consists of intravenous administration of 5% hypertonic saline (sodi

Eligibility

Sex/Gender

Male

Age

40 Years to 70 Years

Inclusion criteria

Inclusion criteria: male patients Aged between 40 to 70 years American Society of Anesthesiologists (ASA) physical status class I or II Candidates for elective urologic surgery Spinal anesthesia plan

Exclusion criteria

Exclusion criteria: Body mass index greater than 35 Body mass index less than 18 Preoperative hypernatremia Preoperative hyponatremia Preoperative electrolyte imbalance Renal failure Patient refusal

Design outcomes

Primary

Measure	Time frame
Systolic blood pressure. Timepoint: 5 minutes before fluid administration, 5 minutes after fluid administration, every 15 minutes until the end of surgery, and postoperatively in the recovery room. Method of measurement: Automated digital blood pressure monitor.;Heart rate. Timepoint: 5 minutes before fluid administration, 5 minutes after fluid administration, every 15 minutes until the end of surgery, and postoperatively in the recovery room. Method of measurement: Digital Heart rate monitor.	—

Measure

Time frame

Systolic blood pressure. Timepoint: 5 minutes before fluid administration, 5 minutes after fluid administration, every 15 minutes until the end of surgery, and postoperatively in the recovery room. Method of measurement: Automated digital blood pressure monitor.;Heart rate. Timepoint: 5 minutes before fluid administration, 5 minutes after fluid administration, every 15 minutes until the end of surgery, and postoperatively in the recovery room. Method of measurement: Digital Heart rate monitor.

—

Secondary

Measure	Time frame
The level of plasma sodium. Timepoint: Once before spinal anesthesia and once at the end of surgery. Method of measurement: Blood test using an automated clinical chemistry analyzer.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactShekoufeh Behdad

Yazd University of Medical Sciences

behdad90@gmail.com+98 35 3183 3634

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026