Investigating the effect of norepinephrine infusion to prevent hypotension in spinal anesthesia in women candidates for non-emergency caesarean section

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20100102002963N37

Enrollment

Registered

2024-08-19

Start date

2024-09-21

Completion date

Unknown

Last updated

2024-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hemodynamic variables and hypotension after spinal anesthesia in the women undergoing cesarean section. Postprocedural hypotension

Interventions

Intervention 1: Intervention group: In this group, norepinephrine is infused at a dose of 0.01 µg per minute from 10 minutes before spinal anesthesia to 10 minutes after the birth of the baby. Interve

Eligibility

Sex/Gender

Female

Age

20 Years to 35 Years

Inclusion criteria

Inclusion criteria: All term pregnant women candidates for non-emergency caesarean surgery aged 20 to 35 and ASA class ll

Exclusion criteria

Exclusion criteria: Lack of patient consent to participate in the study Severe heart, kidney, lung and liver disease Pre-eclampsia and eclampsia diseases and vaginal bleeding and all cases of emergency cesarean section Addiction to drugs and psychotropic substances History of using drugs that affect the patient's hemodynamics

Design outcomes

Primary

Measure	Time frame
Mean Arterial Pressure. Timepoint: Before the injection of the study drug, immediately after the spinal anesthesia and then every three minutes until the birth of the baby and then every 5 minutes until the end of surgery. Method of measurement: Using monitoring device.;Heart Rate. Timepoint: Before the injection of the study drug, immediately after the spinal anesthesia and then every three minutes until the birth of the baby and then every 5 minutes until the end of surgery. Method of measurement: Using monitoring device.;PH of the baby's umbilical cord. Timepoint: Immediately after birth. Method of measurement: Arterial blood gas analysis.;Apgar score of the baby. Timepoint: Minutes 1 and 5 after birth. Method of measurement: examination.;Systolic blood pressure. Timepoint: Before the injection of the study drug, immediately after the spinal anesthesia and then every three minutes until the birth of the baby and then every 5 minutes until the end of surgery. Method of measurement: Using monitoring device.;Diastolic Blood Pressure. Timepoint: Before the injection of the study drug, immediately after the spinal anesthesia and then every three minutes until the birth of the baby and then every 5 minutes until the end of surgery. Method of measurement: Using monitoring device.	—

Measure

Time frame

Mean Arterial Pressure. Timepoint: Before the injection of the study drug, immediately after the spinal anesthesia and then every three minutes until the birth of the baby and then every 5 minutes until the end of surgery. Method of measurement: Using monitoring device.;Heart Rate. Timepoint: Before the injection of the study drug, immediately after the spinal anesthesia and then every three minutes until the birth of the baby and then every 5 minutes until the end of surgery. Method of measurement: Using monitoring device.;PH of the baby's umbilical cord. Timepoint: Immediately after birth. Method of measurement: Arterial blood gas analysis.;Apgar score of the baby. Timepoint: Minutes 1 and 5 after birth. Method of measurement: examination.;Systolic blood pressure. Timepoint: Before the injection of the study drug, immediately after the spinal anesthesia and then every three minutes until the birth of the baby and then every 5 minutes until the end of surgery. Method of measurement: Using monitoring device.;Diastolic Blood Pressure. Timepoint: Before the injection of the study drug, immediately after the spinal anesthesia and then every three minutes until the birth of the baby and then every 5 minutes until the end of surgery. Method of measurement: Using monitoring device.

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Secondary

Measure	Time frame
Drop in systolic blood pressure below 90 mm Hg. Timepoint: Before the injection of the study drug, immediately after the spinal anesthesia and then every three minutes until the birth of the baby and then every 5 minutes until the end of surgery. Method of measurement: Using monitoring device.;Bradycardia(drop in heart rate below 50/ min). Timepoint: Before the injection of the study drug, immediately after the spinal anesthesia and then every three minutes until the birth of the baby and then every 5 minutes until the end of surgery. Method of measurement: Using monitoring device.	—

Measure

Time frame

Drop in systolic blood pressure below 90 mm Hg. Timepoint: Before the injection of the study drug, immediately after the spinal anesthesia and then every three minutes until the birth of the baby and then every 5 minutes until the end of surgery. Method of measurement: Using monitoring device.;Bradycardia(drop in heart rate below 50/ min). Timepoint: Before the injection of the study drug, immediately after the spinal anesthesia and then every three minutes until the birth of the baby and then every 5 minutes until the end of surgery. Method of measurement: Using monitoring device.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Shekoufeh Behdad

Yazd University of Medical Sciences

drbehdad@ssu.ac.ir0098 35 8231932

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026