Comparison of the effect of two tranquilizer oral drugs alprazolam and zolpidem on patient,s anxiety before surgery andblood pressure and heart rate before induction of general anesthesia

Comparison of the effect of oral administration of alprazolam and zolpidem on patient,s anxiety before surgery and hemodynamic variables before induction of anesthesia

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20100102002963N31

Enrollment

Registered

2021-05-02

Start date

2021-04-21

Completion date

Unknown

Last updated

2021-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The effect of drug type on anxiety before induction of anesthesia.

Interventions

Intervention 1: Patients in the first group are given oral alprazolam (0.5 mg) the night before surgery. Intervention 2: Patients in the second group are given oral zolpidem (5 mg) the night before su

Eligibility

Sex/Gender

Female

Age

20 Years to 60 Years

Inclusion criteria

Inclusion criteria: Includes all female patients undergoing abdominal surgery for women referred to Shahid Sadoughi Hospital in Yazd

Exclusion criteria

Exclusion criteria: Existence of moderate to severe systemic disease history of using of sedative or tranquilizer drugs history of addiction to opioids or any sedative or psychotropic drugs patient disagreement for cooperation in this study

Design outcomes

Primary

Measure	Time frame
Anxiety score. Timepoint: Before administration of study drug and before induction of anesthesia. Method of measurement: VAS(0-10).;Systolic blood pressure. Timepoint: Before administration of study drug and before induction of anesthesia. Method of measurement: Using monitoring device.;Diastolic blood pressure. Timepoint: Before administration of study drug and before induction of anesthesia. Method of measurement: Using monitoring device.;Mean arterial pressure. Timepoint: Before administration of study drug and before induction of anesthesia. Method of measurement: Using monitoring device.;Heart Rate. Timepoint: Before administration of study drug and before induction of anesthesia. Method of measurement: Using monitoring device.	—

Measure

Time frame

Anxiety score. Timepoint: Before administration of study drug and before induction of anesthesia. Method of measurement: VAS(0-10).;Systolic blood pressure. Timepoint: Before administration of study drug and before induction of anesthesia. Method of measurement: Using monitoring device.;Diastolic blood pressure. Timepoint: Before administration of study drug and before induction of anesthesia. Method of measurement: Using monitoring device.;Mean arterial pressure. Timepoint: Before administration of study drug and before induction of anesthesia. Method of measurement: Using monitoring device.;Heart Rate. Timepoint: Before administration of study drug and before induction of anesthesia. Method of measurement: Using monitoring device.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr.Shokofe Behdad

Yazd University of Medical Sciences

drbehdad@ssu.ac.ir+98 35 3822 1386

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026