Comparison of the effect of intravenous labetalol with intravenous lidocaine on hemodynamic variables during laryngoscopy and endotracheal intubation and postoperative nausea and vomiting in patients undergoing abdominal surgery.
Conditions
Interventions
Intervention 1: Intervention group1: In this group, 10 mg of labetalol, from Kern pharma company is injected intravenously and once immediately before induction of general anesthesia to eligible patie
Sponsors
Azad Islamic University Of Yazd
Eligibility
Sex/Gender
Female
Age
25 Years to 65 Years
Inclusion criteria
Inclusion criteria: All women candidates for abdominal surgery All women between the ages of 25 and 65 years All women with systolic blood pressure between 90 mm hg and 160 mm Hg All women with normal body mass index All women with diastolic blood pressure between 70 and 100 mm Hg American Society of Anesthesiologists (ASA) class 1 :a normal healthy patient ,for Example: Fit, nonobese (BMI under 30), a nonsmoking patient with good exercise tolerance. American Society of Anesthesiologists (ASA) class 2 : a patient with a mild systemic disease ,for Example: Patients with no functional limitations and a well-controlled disease (for example treated hypertension, obesity with BMI under 35, frequent social drinker or a cigarette smoker)
Exclusion criteria
Exclusion criteria: Arterial hypertension Ischemic heart disease Heart failure Pulmonary disease Addiction Renal disease Liver disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Determining and comparing the incidence of hypotension side effects (systolic blood pressure < 9 ) or a drop of more than 20% of the base rate. Timepoint: Immediately after the operation in recovery room. Method of measurement: Monitoring in the recovery room with a blood pressure monitor connected to the monitor and recording information in a questionnaire.;Changes in systolic blood pressure. Timepoint: Immediately before drug injection Immediately before laryngoscopy Immediately after intubation Immediately after skin incision. Method of measurement: Operating room monitoring with Blood pressure cuf connected to the monitor and recording information in a questionnaire.;Determining and comparing the incidence of bradycardia (heart rate <50 ). Timepoint: Immediately after the operation in recovery room. Method of measurement: Monitoring in the recovery room with a blood pressure monitor connected to the monitor and recording information in a questionnaire.;Determining and comparing the incidence of vomiting and nausea. Timepoint: Immediately after the operation in recovery room. Method of measurement: Question from the patient and registration in the questionnaire.;Changes in diastolic blood pressure. Timepoint: Immediately before drug injection Immediately before laryngoscopy Immediately after intubation Immediately after skin incision. Method of measurement: Operating room monitoring with Blood pressure cuff connected to the monitor and recording information in a questionnaire.;Changes in mean arterial blood pressure. Timepoint: Immediately before drug injection Immediately before laryngoscopy Immediately after intubation Immediately after skin incision. Method of measurement: Operating room monitoring with Blood pressure cuff connected to the monitor and recording information in a questionnaire.;Changes in heart rates. Timepoint: Immediately before drug injection Immediately before laryngoscopy Immediately after intubation Immediately after skin incision. Method | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Shekoufeh Behdad
Yazd University of Medical Sciences
Outcome results
None listed