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Comparison of the effect of sertraline and midodrine in improving blood pressure during hemodialysis

A comparative study of the effect of sertraline and midodrine in improving blood pressure during hemodialysis in patients with chronic renal failure, a double-blind clinical trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20100102002954N29
Enrollment
82
Registered
2023-10-10
Start date
2023-10-23
Completion date
Unknown
Last updated
2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypotension of hemodialysis. Hypotension of hemodialysis

Interventions

Intervention 1: Intervention group: in the first intervention group, 50 mg of sertraline tablets half an hour before the start of dialysis will be administered for 4 weeks, and after a two-week wash o

Sponsors

Shahroud University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
15 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients undergoing permanent hemodialysis for at least 3 months, who have experienced hypotension during dialysis in at least 50% of hemodialysis cases; Performing at least 3 hours of hemodialysis at least 3 times a week; Stable vital signs; Having informed consent to participate in the research.

Exclusion criteria

Exclusion criteria: The presence of severe and relatively severe coagulation problems; The presence of chronic lung and liver disease at the same time; The presence of any mental illness that takes SSRI drugs.

Design outcomes

Primary

MeasureTime frame
Systolic blood pressure value. Timepoint: Once every hour during hemodialysis. Method of measurement: Sphygmomanometer.;Diastolic blood pressure value. Timepoint: Once every hour during hemodialysis. Method of measurement: Sphygmomanometer.

Secondary

MeasureTime frame
Number of intradialytic hypotension episodes in each group. Timepoint: Dialysis even sessions. Method of measurement: Observation by educated and qualified nurse.;Frequency of adverse drug reactions in each intervention group. Timepoint: From the start to the end of each medication intervention in each group. Method of measurement: Patient interview.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Zahra Amirkhanloo

Shahroud University of Medical Sciences

zahra16.khanlu@gmail.com+98 23 3234 2000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026