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Comparing the effect of levofloxacin with azithromycin in improving pulmonary function of patients with bronchiectasis

Comparative study of the effect of levofloxacin with azithromycin in improving pulmonary function in patients with exacerbated bronchiectasis, a double-blind clinical trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20100102002954N28
Enrollment
72
Registered
2022-09-01
Start date
2022-09-23
Completion date
Unknown
Last updated
2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bronchiectasis. Bronchiectasis with (acute) exacerbation

Interventions

Intervention 1: Intervention group: For patients in the intervention group, after justifying the patients and providing the necessary training, routine treatment includes: use of oxygen, bronchodilato

Sponsors

Shahroud University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
15 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients with definite diagnosis of aggravated non-fibrocystic bronchiectasis disease; Not having moderate to severe heart failure (EF>50); Stable vital signs; Having a controlled and stable drug regimen (according to the opinion of a pulmonologist) during the study; Informed consent to participate in research.

Exclusion criteria

Exclusion criteria: Gastrointestinal problems such as severe nausea and vomiting; The presence of various cancers of the respiratory system; The presence of chronic kidney and liver disease at the same time; History of any surgery on the respiratory system at least in the last year; A history of receiving any antibiotics in the last month; A history of receiving any corticosteroid drugs in the past month; Pregnancy and breastfeeding.

Design outcomes

Primary

MeasureTime frame
Measuring oxygen saturation (o2sat). Timepoint: Once every two weeks. Method of measurement: Standard method with pulse oximetry device.;Measurement of lung volumes and capacities. Timepoint: Once every two weeks. Method of measurement: Standard method with spirometer.

Secondary

MeasureTime frame
Measuring discomfort from breathing (Dyspnea). Timepoint: Once every two weeks. Method of measurement: Using standard Borg questionnaire.;Measurement of white blood cells. Timepoint: Once every two weeks. Method of measurement: By standard laboratory method.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Bibimahsa Forghani

Shahroud University of Medical Sciences

daaroo85@yahoo.com+98 23 3234 2000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026