Early neonatal sepsis. Other sepsis
Conditions
Interventions
Intervention 1: Intervention group: After initial and routine procedures including NICU admission, serum therapy and oxygen therapy, and stabilization of vital signs, ampicillin 50 mg / kg with cefota
Sponsors
Shahroud University of Medical Sciences
Eligibility
Sex/Gender
All
Age
1 Days to 7 Days
Inclusion criteria
Inclusion criteria: Infants with early sepsis in the first 7 days of life; Existence of respiratory distress, hypoxia or symptoms of acute respiratory distress syndrome; Poor perfusion or urinary output less than 0.5 cc / kg / hr; Metabolic acidosis with pH <7.2; Cardiovascular instability with a heart rate of less than 160 beats per minute; Decreased infant reflexes; Severe cyanosis; Frequent or prolonged seizures; Increase in body temperature to more than 38.5 or less than 36 ° C axillary; Apnea; Severe abdominal distension; And informed consent of parents to participate in the research.
Exclusion criteria
Exclusion criteria: Infants with major congenital anomalies; Severe prematurity and less than 28 weeks; Very low birth weight (less than 1500 g); Congenital heart disease; Severe asphyxia (Apgar 5 minutes less than 5);
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Duration of making CRP marker negative. Timepoint: At the beginning and during the study. Method of measurement: laboratory tests.;Need for intubation and mechanical ventilarion. Timepoint: During the study. Method of measurement: Checking patient records.;Metabolic acidosis. Timepoint: During the study. Method of measurement: Laboratory test (ABG). | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of hospitalization. Timepoint: At the end of the study. Method of measurement: The time between the time / date of hospitalization and the time / date of discharge from the hospital, expressed in hours.;Mortality rate. Timepoint: At the end of the study. Method of measurement: Mortality rate refers to the number of deaths among these infants, expressed as a percentage. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Mahya Esmaili
Shahroud University of Medical Sciences
Outcome results
None listed