schizophrenia. Paranoid schizophrenia
Conditions
Interventions
Intervention 1: Intervention group: Antipsychotic medication combined with 100 mg/day spironolacton as intervention group for 8 weeks. Intervention 2: Control group: An antipsychotic combined with pla
Sponsors
Sanandaj University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: Diagnosis of Schizophrenia based on DSM-5 criteria Age between 18-55 years old Chronic Schizophrenia- duration of the disorder more than 2 years Minimum score of 20 in negative sub score being stable on antipsychotic for the last 2 months(6 months for clozapine)
Exclusion criteria
Exclusion criteria: Any serious medical or neurological problem IQ less than 70. Substance dependence during the last 6 months(except for nicotine and caffeine) receiving ECT during the last 2 months Acute or chronic systemic diseases History of head trauma exacerbation of symptoms(developing the active phase) hypersensitivity to spironolacton post-psychotic depression gynecomastia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of schizophrenia. Timepoint: Baseline and weeks 2-4-8 after beginning of treatment. Method of measurement: by Positive and Negative Symptoms Scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFarzin Rezaei
Sanandaj University of Medical Sciences
Outcome results
None listed