Neonatal jaundice. Neonatal jaundice from other specified causes
Conditions
Interventions
Intervention 1: Intervention group 1: Neonates receiving phototherapy and Ursodeoxycholic acid (10 mg / kg / day every 12 hours to 48 hours). Ursodeoxycholic acid is a 300 mg capsule manufactured by
Sponsors
Mazandaran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
2 Days to 14 Days
Inclusion criteria
Inclusion criteria: Exclusive breast fed neonates Neonates with age of 2-14 days Direct bilirubin less than 15% of total serum billirubin or less than 1.5 mg/dl Neonates weighing between 2500 to 4000 grams. Neonates with jaundice and glucose 6-phosphate dehydrogenase deficiency require admission and phototherapy.
Exclusion criteria
Exclusion criteria: Neonates with sepsis diagnosis Blood group or Rh incompatibility between mother and neonate Direct hyperbilirubinemia Major congenital anomalies Need to exchange transfusion at the time of admission previous use of drugs like phenobarbital or cotoneaster History of previous exchange transfusion Previous phototherapy Infants of diabetic mother Spherocytosis or elliptocytosis in peripheral blood smear Evidence of severe hemolysis, Retic=5%
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean total serum bilirubin level based on Mg/dl. Timepoint: 12, 24, 48 and 72 hours after intervention. Method of measurement: With the Diazo method and the kits of Tehran Pars ?Azmoon Co. | — |
Secondary
| Measure | Time frame |
|---|---|
| The percentage of total serum bilirubin reduction to the initial bilirubin. Timepoint: 24 hours after admission. Method of measurement: With the Diazo method and the kits of Tehran Pars Azmoon Co.;Duration of phototherapy. Timepoint: At discharge time. Method of measurement: Phototherapy's timer to hour.;Duration of admission. Timepoint: At discharge time. Method of measurement: Patient's file observation and documantation.;Duration of intensive phototherapy. Timepoint: At discharge time. Method of measurement: Patient's file observation and documantation.;Need to exchange. Timepoint: During admission. Method of measurement: Patient's file observation and documantation.;Need to re-hospitalization after discharge. Timepoint: 14 days of life. Method of measurement: Patient's file observation and documantation.;The necessary time in which, first total serum bilirubin level reaches to less than 10mg/d. Timepoint: During admission. Method of measurement: Patient's file observation and documantation. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactRoya Farhadi
Mazandaran University of Medical Sciences
Outcome results
None listed