Intubation weaning.
Conditions
Interventions
Intervention 1: Intervention group: In the intervention group, in addition to the routine care provided in the control group, nandrolone will be administered at a dose of 100 mg in women and 200 mg in
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Inability to wean the patient Unsuccessful weaning of the patient Informed consent of the legal guardian of the patient to participate in the study Stable vital signs Poisoned patients who have been on mechanical ventilation for more than seven days Have the ability to perform physiotherapy Be on TPN for three days before receiving nandrolone
Exclusion criteria
Exclusion criteria: The presence of underlying lung disease leading to respiratory failure The presence of non-invasive ventilation History of allergy to nandrolone Pregnancy and lactation in female patients Unwillingness to participate in the study Prostate or breast cancer Septic shock requiring vasopressor support Active heart disease (myocardial infarction within the previous 2 weeks or ejection fraction 3 g/day) Increased liver enzymes (alanine aminotransferase > 5× normal) and impaired bilirubin excretion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Duration of intubation. Timepoint: Every 24 hours after 7 days. Method of measurement: Number of days of intubation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Rapid shallow breathing index (RSBI). Timepoint: Every 24 hours. Method of measurement: Breaths per minute.;Obstructive pressure (P0.1). Timepoint: Every 24 hours. Method of measurement: cmH2O.;Maximum negative pressure (NIF). Timepoint: Every 24 hours. Method of measurement: percentage. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactBabak Mosftafa zade
Shahid Beheshti University of Medical Sciences
Outcome results
None listed