Hemodialysis patients. Dependence on renal dialysis
Conditions
Interventions
Intervention 1: Intervention group: Patients undergoing hemodialysis who will receive a specified amount of dark chocolate daily for a specified duration, in addition to their usual diet. Intervention
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patient's consent to participate in the study and signify informed consent form The number of hemodialysis three times per week At least three months of history of hemodialysis BMI>30
Exclusion criteria
Exclusion criteria: Active infectious diseases including hepatitis and malignancies Allergy or intolerance to dark chocolate in the intervention group Regular consumption of dark chocolate in the daily diet Being on the threshold of kidney transplantation Consumption of antioxidant supplements or similar herbal products in the past 3 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lipoprotein (a). Timepoint: The beginning of the study (before the start of the intervention), the end of the study (8 weeks after the start of the intervention). Method of measurement: Immunoturbidometric method. | — |
Secondary
| Measure | Time frame |
|---|---|
| Apolipoprotein A-1. Timepoint: The beginning of the study (before the start of intervention), the end of the study (8 weeks after the start of the intervention). Method of measurement: Immunoturbidometric method.;Apolipoprotein B. Timepoint: The beginning of the study (before the start of intervention), the end of the study (8 weeks after the start of the intervention). Method of measurement: Immunoturbidometric method.;Inflammatory factor IL-6. Timepoint: The beginning of the study (before the start of intervention), the end of the study (8 weeks after the start of the intervention). Method of measurement: ELISA test.;MDA. Timepoint: The beginning of the study (before the start of intervention), the end of the study (8 weeks after the start of the intervention). Method of measurement: ELISA test.;Lipid profile. Timepoint: The beginning of the study (before the start of intervention), the end of the study (8 weeks after the start of the intervention). Method of measurement: TG, HDL-C and TC concentrations will be measured calorimetrically and LDL-C concentrations will be calculated using the Friedwald formula. .LDL-C (mg/dL) = TC (mg/dL) - HDL-C (mg/dL) – (TG (mg/dL)/5).;Anxiety and depression score. Timepoint: The beginning of the study (before the start of intervention), the end of the study (8 weeks after the start of the intervention). Method of measurement: Hospital Anxiety and Depression Scale questionnaire.;Health-related quality of life score. Timepoint: The beginning of the study (before the start of intervention), the end of the study (8 weeks after the start of the intervention). Method of measurement: Kidney Disease Quality of Life-36 questionnaire.;Blood pressure. Timepoint: The beginning of the study (before the start of intervention), the end of the study (8 weeks after the start of the intervention). Method of measurement: Digital blood pressure monitor.;Anthropometric indices. Timepoint: The beginning of the study (before the start of intervention), | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFarzad Shidfar
Iran University of Medical Sciences
Outcome results
None listed