Inflammatory bowel disease, ulcerative colitis. Ulcerative colitis
Conditions
Interventions
Intervention 1: Intervention group: The group receiving the supplement of 500 mg of dry pomegranate peel extract for eight weeks. In this study, the supplements of Adib Elixir herbal products company
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patient consent to participate in the study 2. Aged 18 years or older (age = 18 years) 3. BMI above 18.5 and less than 30 kg/m2 (30 = BMI = 18.5) 4. Diagnosis of ulcerative colitis by a specialist 5. People with mild to moderate ulcerative colitis according to specialist diagnosis and the Partial Mayo scoring index 6. Users of oral drugs of the 5-aminosalicylic acid group (pentasa, mesalazine or asacol, sulfasalazine) as well as immunomodulatory drugs (azathioprine, methotrexate, prograf, selpest or 6-mercaptopurine).
Exclusion criteria
Exclusion criteria: 1. Changing the type and dosage of the drug used during the last month 2. Pregnant or lactating women 3. Suffering from other diseases, including digestive diseases, autoimmune diseases, cancer, inflammatory and infectious diseases 4. Use of multivitamin-mineral, omega-3, polyphenolic, antioxidants, and herbal supplements during the past month (except for commonly prescribed supplements in ulcerative colitis) 5. Use of corticosteroids, NSAIDs (profen, aspirin and diclofenac), and anti-TNF drugs (Cinnora or Adalimumab, Infliximab or Remicade)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Interleukin 6. Timepoint: ??At the beginning (before starting the intervention ) and the end of the study (after the end of the eighth week). Method of measurement: Blood test.;Interleukin 10. Timepoint: At the beginning (before starting the intervention ) and the end of the study (after the end of the eighth week). Method of measurement: Blood test.;Disease activity index. Timepoint: At the beginning (before starting the intervention ) and the end of the study (after the end of the eighth week). Method of measurement: Disease activity index questionnaire.;Quality of life. Timepoint: At the beginning (before starting the intervention ) and the end of the study (after the end of the eighth week). Method of measurement: IBD quality of life questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure. Timepoint: At the beginning (before starting the intervention ) and the end of the study (after the end of the eighth week). Method of measurement: Upper arm blood pressure digital monitor. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFarzad Shidfar
Iran University of Medical Sciences
Outcome results
None listed