Multiple sclerosis. Multiple sclerosis
Conditions
Interventions
Intervention 1: Intervention group: The intervention group receives two 90 mg allagic acid capsules daily for 12 weeks before lunch and dinner. Intervention 2: Control group: The placebo group takes t
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: Willingness to cooperate Age range 18 to 55 years Depression according to Beck's questionnaire (score above 10) No change in the dose of antidepressant medication in the last three months Diagnosis of MS by a neurologist Patients are at recurrence and recovery EDSS <5.5
Exclusion criteria
Exclusion criteria: Take nutritional, antioxidant, and ellagic acid supplements for a month before the study (except for routine supplements, which are part of the treatment plan for all patients, such as vitamin D) Pregnancy and lactation Drug abuse History of diabetes and other chronic diseases History of other autoimmune diseases Occurrence of recurrence of the disease during study Taking corticosteroids, estrogens, progesterone, immunosuppressants, diuretics during last month Dose changes and the type of medication used during study Change in physical activity Acceptance rate of less than 90% of supplementation Lack of willingness to cooperate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| IFN-?. Timepoint: At the beginning and end of the intervention. Method of measurement: Laboratory kit. | — |
Secondary
| Measure | Time frame |
|---|---|
| Depression score. Timepoint: The beginning and the end of the intervention. Method of measurement: Beck questionnaire.;Nrf2. Timepoint: The beginning and end of the intervention. Method of measurement: Laboratory kit.;NO. Timepoint: The beginning and end of the intervention. Method of measurement: Laboratory kit.;BDNF. Timepoint: The beginning and the end of the intervention. Method of measurement: Laboratory kit.;Cortisol. Timepoint: The beginning and the end of the intervention. Method of measurement: Laboratory kit.;Serotonin. Timepoint: The beginning and the end of the intervention. Method of measurement: Laboratory kit.;IDO gene expression. Timepoint: The beginning and end of the intervention. Method of measurement: Real Time RT-PCR.;EDSS. Timepoint: The beginning and the end of the intervention. Method of measurement: EDSS QUESTIONNAIRE. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFarzad Shidfar
Iran University of Medical Sciences
Outcome results
None listed