Ulcerative colitis. Ulcerative colitis
Conditions
Interventions
Intervention 1: Intervention group: cap selenium 200 microgram 1/d. Intervention 2: Control group: Rice flour Cap 1/d.
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Volunteering participation in the study The definitive diagnosis of injured colitis by using histological methods on mucosal biopsy of the colon, rectum and jejunium by the physician in the mild to moderate phase The consumer of only one of the 5-amino-salicylic acid Pentasa, mesalazine or asacole), as well as an immunomodulatory drug such as azathioprine (maximum one tablet/d) age: 18= 30<BMI =18/5
Exclusion criteria
Exclusion criteria: Change in the type and dosage of the drug during the past month The onset of some diseases such as : autoimmune diseases, cancer, inflammatory and infectious diseases) Pregnancy or lactation in women or the use of contraceptives The use of multi-vitamin - Mineral supplements, omega-3, polyphenols and antioxidants during one previous month The use of cholesterol lowering drugs (statins), NSAIDs, aspirin and diclofenac, antihistamines, anticoagulants, anti-TNF drugs, barbiturates, corticosteroids) during one previous month
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of patients in clinical remission at the end of treatment, defined as SCCAI score. Timepoint: at baseline and end of study. Method of measurement: [Simple Clinical Colitis Activity Index] Questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of life. Timepoint: at first and end of study. Method of measurement: IBDQ- 9 questionnaire.;Interleukin 17. Timepoint: at baseline and end of study. Method of measurement: ELISA kit.;Interleukin 10. Timepoint: at baseline and end of study. Method of measurement: ELISA kit.;PGC1-a gene expression. Timepoint: at baseline and end of study. Method of measurement: Real Time RT-PCR.;Sirt1 gene expression. Timepoint: at baseline and end of study. Method of measurement: Real Time RT-PCR. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFarzad Shidfar
Iran University of Medical Sciences
Outcome results
None listed