Chronic heart failure. Cardiac, heart or myocardial failure NOS
Conditions
Interventions
Intervention 1: Intervention group: Consumption of Probiotic yogurt (300 gr/day for 10 weeks). Probiotic yogurt is prepared in the form of low-fat yogurt (1.5% fat) containing 10? cfu /gr of Lactobaci
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
30 Years to 70 Years
Inclusion criteria
Inclusion criteria: Age range 30 to 70 years Having common symptoms of heart failure for at least 1 month decreased LVEF (=40%) Being in one of the NYHA classification steps 1-3 Desire to participate in the study and sign a written informed consent
Exclusion criteria
Exclusion criteria: suffering or having chronic and acute liver (hepatitis B, C, etc.) Diseases and other, diabetes, thyroid disorders, severe renal dysfunction (creatinine more than 300 millimol/liter), pulmonary disease, known inflammatory and autoimmune diseases, Cancer, Rheumatoid Arthritis, Acute Infection taking any nutritional supplement during the past month smoking and using narcotic drugs Lactose intolerance and allergy to dairy products taking Corticosteroid drug in the last 4 weeks taking antibiotics over the past 3 months History of Gastrointestinal Surgery Taking anti-inflammatory drugs other than low dose of aspirin (one per day) Having an artificial heart valve History of rheumatic heart disease Pregnancy and lactation taking insulin body mass index more than 30 Kilogram/meter²
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum pentraxin3. Timepoint: Measurement of serum pentraxin3 at the beginning of the study (before the intervention) and the end of the study (10 weeks after starting probiotic yogurt consumption). Method of measurement: ELISA kit.;Serum oxidized low density lipoprotein. Timepoint: Measurement of serum oxidized low density lipoprotein at the beginning of the study (before the intervention) and the end of the study (10 weeks after starting probiotic yogurt consumption). Method of measurement: ELISA kit. | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum N-terminal prohormone of brain natriuretic peptide. Timepoint: Measurement of Serum N-terminal prohormone of brain natriuretic peptide at the beginning of the study (before the intervention) and the end of the study (10 weeks after starting probiotic yogurt consumption). Method of measurement: ELISA kit.;Serum Apolipoprotein B100. Timepoint: Measurement of Serum Apolipoprotein B100 at the beginning of the study (before the intervention) and the end of the study (10 weeks after starting probiotic yogurt consumption). Method of measurement: Immunoturbidimetry.;Serum Asymmetric dimethylarginine. Timepoint: Measurement of Serum Asymmetric dimethylarginine at the beginning of the study (before the intervention) and the end of the study (10 weeks after starting probiotic yogurt consumption). Method of measurement: ELISA kit.;Serum lecithin Cholesterol acyl transferase activity. Timepoint: Measurement of Serum lecithin Cholesterol acyl transferase activity at the beginning of the study (before the intervention) and the end of the study (10 weeks after starting probiotic yogurt consumption). Method of measurement: ELISA kit.;SCD163 to sTWEAK ration. Timepoint: Measurement of Serum sCD163 to sTWEAK ration at the beginning of the study (before the intervention) and the end of the study (10 weeks after starting probiotic yogurt consumption). Method of measurement: ELISA kit.;Serum urea nitrogen. Timepoint: Measurement of Serum urea nitrogen at the beginning of the study (before the intervention) and the end of the study (10 weeks after starting probiotic yogurt consumption). Method of measurement: Enzymatic colorimetric. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr.Farzad Shidfar
Iran University of Medical Sciences
Outcome results
None listed