Infantile spasms. Other generalized epilepsy and epileptic syndromes
Conditions
Interventions
Intervention 1: Intervention group1: Topiramate tablet of 25 or 50 mg from Darou Pakhsh Co, Iran with dosage of 3- 9mg/kg/day divided into two doses for three months. Intervention 2: Intervention grou
Sponsors
Yazd University of Medical Sciences
Eligibility
Sex/Gender
All
Age
2 Months to 1 Years
Inclusion criteria
Inclusion criteria: Age range of 2 months-1 year Having infantile spasms based on definition of the International League Against Epilepsy Resistance of their seizure to treatment of 2 mg/kg/day prednisolone for two months Not used of other antiepileptic drugs
Exclusion criteria
Exclusion criteria: Discontinuation of levetiracetam and topiramate usage for more than one week Allergy to levetiracetam and topiramate Irregular drugs usage Not returning for follow up
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Daily frequency of seizure. Timepoint: Before and after three months of treatment. Method of measurement: Asking from patient parents.;Treatment response. Timepoint: Before and after three months of treatment. Method of measurement: Asking from patient parents. | — |
Secondary
| Measure | Time frame |
|---|---|
| Frequency of more than 50 % of reduction in daily frequency of seizure. Timepoint: Before and three months after treatment. Method of measurement: Asking from parents of patient.;Clinical side effects. Timepoint: During three months of treatment. Method of measurement: Asking from parents of patient. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr.Nahid Zareeian
Yazd University of Medical Sciences
Outcome results
None listed