Skip to content

The effect of progesterone to prevent preterm delivery

The effectiveness of daily rectal progesterone to prevent preterm delivery

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20091023002624N28
Enrollment
140
Registered
2018-11-30
Start date
2016-04-20
Completion date
Unknown
Last updated
2019-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Preterm labour and delivery. Condition 2: Preterm labour without delivery. Condition 3: Preterm spontaneous labour with preterm delivery. Condition 4: Preterm spontaneous labour with term delivery. Preterm labour and delivery Preterm labor without delivery Preterm spontaneous labour with preterm delivery Preterm spontaneous labour with term delivery

Interventions

Intervention 1: Intervention group: Micronized progesterone(Tasnim Pharmaceutical Company, Tehran, Iran.) 200 mg daily was administered rectally for up to 36 weeks of gestation. Intervention 2: Contro

Sponsors

Iran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: Gestational age of 26 to 34 weeks Four contractions within 20 minutes or 8 contractions within 60 minutes Cervical dilatation of 1 cm and more Cervical effacement of more than 50%

Exclusion criteria

Exclusion criteria: Ruptured membrane Vaginal bleeding Fetal death Fetal distress and intrauterine growth restriction History of trauma Cervical dilatation of 4 cm and more Systemic disorders Preeclampsia Known uterine abnormalities Smoking Any drug abuse Poly hydramnious & oligo hydramnious Fetal abnormalities Any suspicious intrauterine infection Previous use of tocolitic in present pregnancy Blood pressure lower than 90/50 mmHg Women who continue to have a pregnancy are dangerous to them

Design outcomes

Primary

MeasureTime frame
Gestational age at delivery. Timepoint: Date of delivery. Method of measurement: File.;Delivery under 37 weeks. Timepoint: Date of delivery. Method of measurement: File.

Secondary

MeasureTime frame
Neonatal weight. Timepoint: At birth. Method of measurement: File.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Kashanian

Iran University of Medical Sciences

maryamkashanian@yahoo.com+98 21 5563 3244

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026